Consistency of LGE-MRI Fibrosis and EAM Low-voltage Area

China National Center for Cardiovascular Diseases50 enrolled

Overview

This study aims to: 1. Assess the consistency of LGE-MRI bi-atrial fibrosis and electroanatomical mapping of bi-atrial low voltage region 2. To evaluate the electroanatomical characteristics of different types of fibrosis (dense fibrosis, patchy fibrosis, etc.) in different locations of the left and right atrium; 3. To explore the correlation between preoperative and postoperative bi-atrial fibrosis and long-term recurrence in patients with atrial fibrillation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Atrial Fibrillation

Interventions

LGE-MRI ScanDIAGNOSTIC_TEST

Participants will receive LGE-MRI scan before catheter ablation and 3 months after catheter ablation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Adult patients (≥18 years old) who are willing to participate in this study and can sign informed consent; 2. Atrial fibrillation was diagnosed and catheter ablation was proposed Exclusion Criteria: 1. Left atrial thrombus or left atrial appendage thrombus; 2. Severe chronic obstructive pulmonary disease (FEV1/ FVC\<70%, FEV1\<50% predicted value); 3. Absolute contraindications of anticoagulation therapy; 4. Currently pregnant; 5. Contraindications for LGE-MRI (claustrophobia, pacemaker implantation, eGFR\<30ml/min for renal insufficiency, severe obesity, pregnancy, gadolinium chelating agent allergy, etc.); 6. refuse to participate in the study; 7. other physical or mental incapacity to participate in the study.

Locations (1)

Fuwai Hospital, CAMS&PUMC

Beijing, Beijing Municipality, China

RECRUITING

Outcomes

Primary Outcomes

Consistency of LGE-MRI fibrosis and EAM low-voltage area

Use Registration to match the corresponding spatial points of LGE-MRI and EAM。Each spatial points will contain two types of status(Fibrosis: Yes/No, Low-voltage area: Yes/No). Chi-square test will be used to assess the consistency of fibrosis and low-voltage area.

Time frame: Baseline (at recruit time point)

Data from ClinicalTrials.gov

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