Respiratory Muscle Strength and Aerobic Capacity in Scleroderma

Firat University15 enrolled

Overview

Primary aim of this study was to compare respiratory muscle strength, aerobic capacity, dyspnea, pulmonary function tests and fatigue values with healthy controls. The secondary aim was to evaluate the relationship between respiratory muscle strength and other parameters in these patients and to examine the factors that may affect respiratory muscle strength. Respiratory muscle strength, aerobic capacity, respiratory function tests and fatigue will be evaluated

Scleroderma is a systemic connective tissue disease characterized by progressive thickening of the skin, the etiology of which has not been fully elucidated, in which microvascular damage, immune activation and fibrosis play a role. Primary aim of this study was to compare respiratory muscle strength, aerobic capacity, dyspnea, pulmonary function tests and fatigue values with healthy controls. The secondary aim was to evaluate the relationship between respiratory muscle strength and other parameters in these patients and to examine the factors that may affect respiratory muscle strength. The study will include 15 patients and 15 healthy individuals of the same age and gender. Respiratory muscle strength, aerobic capacity, respiratory function tests and fatigue will be evaluated

Study Type

OBSERVATIONAL

Enrollment

Conditions

Scleroderma

Interventions

Scleroderma GroupOTHER

Scleroderma patients will be evaluated in terms of respiratory muscle strength, aerobic capacity, pulmonary function test and fatigue.

Healthy groupOTHER

Healthy people will be evaluated in terms of respiratory muscle strength, aerobic capacity, pulmonary function test and fatigue.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Being diagnosed with Ssk according to ACR/EULAR criteria * Stable medical treatment for 3 months Exclusion Criteria: * Having a regular exercise habit (doing regular exercise at least once a week for the last 3 months) * Comorbidity with another chronic disease that may affect aerobic capacity or respiratory muscle strength * Having concomitant acute respiratory diseases * Having a smoking habit * History of orthopedic or neurologic disease in the lower extremities that may prevent cycling

Locations (1)

Songul Baglan Yentur

Elâzığ, Turkey (Türkiye)

RECRUITING

Outcomes

Primary Outcomes

Respiratory muscle strength assessment

Respiratory muscle strength will be assessed with an intraoral pressure gauge. These are the intraoral pressures measured at maximal respiration against a valve that closes the airways. When applying MIP, the patient is asked to perform maximal expiration. As a result, the patient is asked to maximally inspire against the closed airway and maintain this for 1-3 seconds. MEP, on the other hand, after maximal inspiration, the patient is asked to perform maximal expiration against the closed airway for 1-3 seconds.

Time frame: 5 minutes

Secondary Outcomes

Aerobic capacity assessment

Aerobic capacity will be assessed using exercise testing. VO2max will be assessed using the Cosmed FitMate Pro® (Cosmed, Italy). The FitMate Pro® includes a turbine flowmeter to measure ventilation and a galvanic fuel cell oxygen sensor to analyze the oxygen fraction in expired gases.

Time frame: 10 minutes

Fatigue assessment

Fatigue will be assessed with the Fatigue Severity Scale (FSS), the Turkish validity and reliability of which was performed by Armutlu et al. This scale includes 9 questions related to fatigue.

Time frame: 2 minutes

Pulmonary function test

Pulmonary function test is routinely performed in Ssk patients. FEV1, DLCO and FEV1/FVC values will be recorded from the patients' files.

Time frame: 5 minutes

Data from ClinicalTrials.gov

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