A Trial of HRS-6209 in Combination With Fulvestrant, Letrozole, HRS-8080, or HRS-1358 in Breast Cancer Patients

Inclusion Criteria: 1. Females aged 18-75 years (inclusive); 2. ECOG performance status (PS) score of 0-1; 3. Patients with histopathologically confirmed metastatic or unresectable locally advanced breast cancer, histopathologically confirmed ER-positive or PR-positive; 4. Menopausal status: 1. Having had bilateral oophorectomy, or aged ≥ 60 years old; or 2. Aged \< 60, natural menopause with E2 and FSH at postmenopausal levels; or 3. Premenopausal or perimenopausal patients, but they should receive LHRH agonists during the study and the treatment should be initiated prior to study treatment. 5. Disease progression evidenced by imaging during or after the last systemic anti-tumor treatment prior to the first dose (limited to the efficacy expansion stage); 6. With at least one extracranial measurable target lesion at baseline per RECIST v1.1; 7. Life expectancy of \> 3 months; 8. The functional level of organs must meet the following requirements : Absolute neutrophil count ≥ 1.5 × 109/L; Platelet count ≥ 90 × 109/L; Hemoglobin ≥ 10 g/dL; Normal blood creatinine or creatinine clearance ≥ 50 mL/min (calculated by standard Cockcroft-Gault formula); Serum albumin ≥ 3.0 g/dL; Total bilirubin ≤ 1.5 × upper limit of normal (ULN); Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 × ULN, or ≤ 5.0 × ULN for patients with liver metastasis; Prothrombin time (PT) and partial thromboplastin time (APTT) ≤ 1.5 × ULN; Urine protein \< 2+ or 24-h urine protein \< 1 g; Left ventricular ejection fraction (LVEF) ≥ 50%; QTcF ≤ 470 msec. 9. Female subjects of childbearing potential should agree to adopt effective contraceptive measures during the study period and within 6 months after the end of the study treatment; female subjects of childbearing potential must have a negative serum HCG test result within 7 days before enrollment in the study and must not be in the lactation; 10. Voluntarily participate in this clinical study, be willing and able to comply with procedures related to clinical visits and study, and understand and have signed written informed consent. Exclusion Criteria: 1. With symptomatic visceral metastases deemed unfit for endocrine therapy by the investigator; 2. With active brain metastases, carcinomatous meningitis, spinal cord compression, or a history of primary tumors of the central nervous system; 3. History of clinically significant cardiovascular disease; 4. Abnormal ECG findings, which are judged by the investigator to be clinically significantand and need to intervene ; 5. With factors that affect oral medication, active gastrointestinal diseases, or other diseases that may obviously affect drug absorption, distribution, metabolism, or excretion; 6. With clinically significant endometrial abnormalities, including but not limited to endometrial hyperplasia and dysfunctional uterine bleeding; 7. Active infection or unexplained fever \> 38.5 °C during the screening period or on the day of first dose; 8. With uncontrollable chronic systemic complications as judged by the investigator. 9. With active autoimmune diseases, history of immunodeficiency and history of autoimmune diseases, history of diseases or syndromes that require systemic corticosteroids or immunosuppressive drugs, other acquired (HIV infection) or congenital immunodeficiency, or history of organ transplantation (including allogeneic bone marrow transplantation); 10. With acute infection or active tuberculosis requiring medication. 11. With a known history of clinically significant liver disease, untreated active hepatitis; 12. Had other concurrent malignant tumors in the past 5 years; 13. Use of moderate and strong CYP3A4 inhibitors within 1 week or moderate and strong CYP3A4 inducers within 2 weeks prior to the first dose; 14. Use of any drugs with the risk of prolonging QT/QTc interval or causing torsade de pointes (TdP) within 4 weeks prior to the first dose, and with previous congenital QT interval prolongation syndrome or a family history of QT interval prolongation; 15. Pregnant or lactating women, or females planning to become pregnant during the study period; 16. With clear history of neural or mental disorders or with history of psychotropic abuse or drug abuse; 19\) Subjects who are expected to receive other anti-tumor therapies or drugs during this study.