Forty healthy adults (i.e., not recruited with respect to any particular diagnosis) are each alternately provided with supplemental oxygen and air via nasal cannula at about 6 Liters per Minute (LPM), while completing memory tests.
Prior studies have reported that supplemental oxygen can confer acute benefits to cognition. Here, the investigators seek to replicate/extend such findings by assessing whether such benefits can be seen using an Inogen oxygen concentrator with subjects with an average age around 65 years old. The investigators include a standard measure of cognition previously reported to be sensitive to supplemental oxygen (2-back test) and a novel, in-development adaptation of a memory test for medical-related content (Medical icons spatial test).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
40
Subjects repeatedly complete memory tests, either first while breathing supplemental oxygen or first while breathing "supplemental air" (in an order randomly assigned).
Two Liberty Place
Philadelphia, Pennsylvania, United States
2 back Memory test performance
\# correct on 2-back test
Time frame: At baseline and 5 mins post-intervention exposure
Memory test performance
New Medical Icons Spatial Test
Time frame: At baseline and 5 mins post-intervention exposure
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