Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants

Inclusion Criteria: 1. Clinical diagnosis of acute ischemic stroke with indication for IVT according to applicable guidelines 2. Time from symptom onset or last known well \<12 hours 3. Admission NIHSS of 2 points or more 4. either DOAC ingestion within 48 hours prior to expected timepoint of IVT bolus, or patient with an ongoing prescription of DOAC, but exact timepoint of last intake not verifiable in the emergency setting. (regardless of whether intravenous thrombolysis was given) OR DOAC prescription (any intake within the last 7 days) and receiving intravenous thrombolysis 5. Informed consent (if obtainable and in those international sites where this is legally required) for the prospective part Exclusion Criteria: 1. Patient refused the use of biological data for research purposes (Switzerland) 2. Any acute or subacute intracranial hemorrhage (ICH) identified by admission CT or MRI on brain scan 3. Documentation of any other absolute contraindications to IVT in the medical record 4. Significant pre-stroke disability (mRS score of 5), including known advanced dementia 5. Known (serious) sensitivity to Alteplase/Tenecteplase or any of the excipients 6. Pregnancy or lactating women.