This study aims to determine the efficacy of nebulising 3% hypertonic saline in improving clinical symptoms and reducing the length of hospital stay in infants with acute bronchiolitis.
Bronchiolitis is the most prevalent disease in infants, especially children younger than two years old. Clinical manifestations vary from mild to severe, even life-threatening respiratory failure. Airway oedema and mucus plugging are the principal pathological features in infants with acute bronchiolitis. Nebulising 3% hypertonic saline solution may reduce these pathological changes, but the evidence remains equivocal.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
140
4ml nebulized three times daily
Standard care
Can Tho Children's Hospital
Can Tho, Vietnam
Improve clinical severity score after three days of treatment with nebulized 3% hypertonic saline.
The clinical severity score is a validated, self-reported instrument assessing clinical severity over treatment. Possible scores range from 0 (mild) to 12 (severity).
Time frame: three days
Shorten the mean length of hospital stays in infants with bronchiolitis after treatment with nebulized 3% hypertonic saline.
The mean length of hospital stays is the days from admission to discharge of all participants.
Time frame: From admission to discharge, up to 14 days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.