A Trial Comparing Efficacy, Tolerability, and Safety of GZR101 Injection Once Daily (OD) and GZR33-70 Injection OD

Change in Fasting Plasma Glucose (FPG)

Change from baseline in fasting plasma glucose (FPG) after 16 weeks of treatment

Time frame: Week 0, Week 16

Change in 7-point SMPG profile

Change from baseline in 7-point SMPG profile after 16 weeks of treatment: the mean and the CV

Time frame: Week 0, Week 16

Incidence and Rate of Treatment-emergent AE/SAEs

A TEAE is defined as an event that had onset date (or increase in severity) during the on-treatment observation period.

Time frame: Week 0, Week 19

Incidence and Rate of hypoglycemia Events

Hypoglycaemia alert episodes (level 1) are defined as episodes that are sufficiently low for treatment with fast-acting carbohydrate and dose adjustment of glucose-lowering therapy with plasma glucose value of equal to or above (\>=) 3.0 and less than (\<) 3.9 mmol/L (\>= 54 and \< 70 mg/dL) confirmed by BG meter. Clinically significant hypoglycaemic episodes (level 2) are defined as episodes that are sufficiently low to indicate serious, clinically important hypoglycaemia with plasma glucose value of less than (\<) 3.0 mmol/L (54 mg/dL). Severe hypoglycaemic episodes (level 3) are defined as episodes that were associated with severe cognitive impairment requiring external assistance for recovery. Severe hypoglycaemic episodes (level 3) are defined as episodes that are associated with severe cognitive impairment requiring external assistance for recovery.

Time frame: Week 0, Week 19