The goal of this observational study is to learn about safety and results of peroperative and intraoperative intravenous Tranexamic acid for diabetic macular tractional detachment eye surgeries . The main question it aims to answer is: Adverse events and their frequency? immediate postoperative bleeding incidence? effective vitrectomy time?
all Patients who agreed and gave informed consent forsurgery as well as to be included in study were included Patients injected INTRAVENOUS TRANEXAMIC ACID 500 mg diluted to 10 ml with normal saline slowly in immediate preoperative period Accordingly, whenever bleeding was anticipated before removing active taut membranes or when bleeder was noted TXA 0.5 g was added upto maximum of 2 g. In Chronic kidney Disease patients dose was kept as maximum of 1.5 g data analysis pack of microsoft excel will be used for statistical analysis. descriptive statistics will be applied. wherever mean of continuous variables is to be compared among subgroups, unpaired students t test will be used. To find any relationship among continuous variables , pearsons correlation or multiple regression will be used from data analysis pack of microsoft excel.
Study Type
OBSERVATIONAL
Enrollment
102
Ahaliafoundation Eye Hospital
Palakkad, Kerala, India
Number of systemic adverse events
Safety of intravenous tranexamic acid
Time frame: intraoperatively and postoperatively 24 hours
Number of systemic adverse events in patients having Chronic kidney disease
Safety of intravenous tranexamic acid in Patients also having Chronic Kidney Disease
Time frame: intraoperatively and postoperatively 24 hours
Surgical time for vitrectomy
Surgical time for vitrectomy that is less view blurring because of intraoperative bleed
Time frame: intraoperatively
Any relation between intraoperative use of Tranexamic acid and labetalol
labetalol dose needed
Time frame: intraoperatively
Number of vitrectomies converted intraoperatively to bimanual technique
Highly complex surgeries
Time frame: intraoperatively
Number of surgeries in which retinectomy required
Instances where it bleeds profusely and surgery could yet be completed successfully
Time frame: intraoperatively
Number of surgeries in which Perfluorocarbon liquid had to be used
PFCL acts as third hand- denotes complexity of surgery
Time frame: intraoperatively
Number of surgeries in which Internal Limiting Membrane peeling done
ilm peeling done after staining retina with Brilliant blue
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Time frame: intraoperatively
Number of eyes having preretinal bleed at the end of surgery
to find efficacy of Tranexamic acid in decreasing immediate post operative bleed
Time frame: immediate postoperatively
Visual acuity change after surgery
improvement in visual acuity
Time frame: 6 months postoperatively