Standard Oxytocin Versus High Dose Oxytocin to Control Postpartum Hemorrhage in High Risk Pregnancy During Elective Cesarean Section

Ain Shams University39 enrolled

Overview

Controlling hemorrhage during and after a cesarean section reduces significantly maternal mortality and morbidity and the present study is important for detection of the effectiveness of routinely increasing the oxytocin dose instead of using the standard dose only in preventing postpartum hemorrhage and additional use of uterotonics in the first 24 hours after cesarean section for high risk pregnancy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Post Partum Hemorrhage

Interventions

OxytocinDRUG

will receive 10 IU oxytocin intravenous bolus over one min and infusion of 10 IU oxytocin in 500 ml of 0.9 saline over four hours.

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * \- Medical disorders ie: Hypertensive diseases with pregnancy - Diabetes Mellitus - Collagen diseases - Coagulopathies - Cardiac diseases - Anemia * History of postpartum hemorrhage * Placental disorders ie: placenta previa * Infertility and ICSI * High Parity * History of Endometriosis * Fetal disorders (IUGR, IUFD, Preterm, Congenital anomalies, oligohydramnios or polyhydramnios, macrosomia) * Preterm labor on uterine relaxants * Twins pregnancy * Patients on antiplatelets and anticoagulants * Uneventful antenatal care Exclusion Criteria: * \- Oxytocin Allergy * Normal uncomplicated pregnancy * Emergency cesarean section * Exhausted uterus due to trial of normal labor * Couvelaire uterus

Outcomes

Primary Outcomes

blood loss

measure blood in suction, towels and pads

Time frame: at the end of the operation

Secondary Outcomes

haemoglobin

by laboratory asessment

Time frame: immediate preoperative

haemoglobin

by laboratory asessment

Time frame: 6 hours postoperative

Data from ClinicalTrials.gov

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