Comparison of Intraperitoneal Bupivacaine Alone or With Dexmedetomidine

RESnTEC, Institute of Research68 enrolled

Overview

For patients with symptomatic cholelithiasis, laparoscopic cholecystectomy (LC) is a customary procedure for treatment these days. After LC, patients may experience considerable pain. This study was performed with the objective of comparing the mean duration of analgesia of intraperitoneal bupivacaine with dexmedetomidine to intraperitoneal bupivacaine alone in patients undergoing laparoscopic cholecystectomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

LAPAROSCOPIC CHOLECYSTECTOMY

Interventions

Bupivacaine injectionDRUG

patients received intraperitoneal bupivacaine 50 ml 0.25% + 5 ml normal saline.

Dexmedetomidine injectionDRUG

Patients were given intraperitoneal bupivacaine 50 ml 0.25% + dexmedetomidine 1 μg/kg with normal saline 5 ml.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients of either gender * Aged between 20 and 70 years * ASA (American Society of Anesthesiologists Classification) physical status I and II * Undergoing Laparoscopic Cholecystectomy under general anesthesia Exclusion Criteria: * Patients sensitive to local anesthetics * Patients with acute cholecystitis, choledocholithiasis, or ascending cholangitis (temperature≥38.6°C, serum bilirubin≥1.2mg/dl, and ultrasound showing common bile duct diameter of ≥1cm). * Patients with uncontrolled diabetes (FBS≥110 mg/dl) * Uncontrolled blood pressure (SBP≥140 mmHg) * Ischemic heart disease (EF≤40%) * Pulmonary dysfunction (FEV≤70 percent of normal)

Locations (1)

Quaid-e-Azam Medical College

Bahawalpur, Punjab Province, Pakistan

Outcomes

Primary Outcomes

Duration of analgesia

The duration of postoperative analgesia was calculated as the time in minutes starting after the dressing of the patient in the operation room until the patient had a VAS≥3.

Time frame: 24 hours

Data from ClinicalTrials.gov

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