The purpose of this study is to understand how the brain controls movement and how Non-invasive Brain Stimulation (NIBS) with a technique called High-density transcranial direct current stimulation (HD-tDCS) can alter brain processes to improve behavior. Participants in this study will be randomized to either HD-tDCS with standard intervention or personalized dose-controlled multifocal network-targeted HD-tDCS. The hypothesis is that dexterous hand function will improve after a standard HD-tDCS dose and increase even more after personalized dose-controlled multifocal network-targeted HD-tDCS.
This project is the first of two projects. The second project will be registered as a separate project in the future and enroll participants from this project.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
40
Participants will have three sessions along with behavioral assessments.
Participants will have three sessions along with behavioral assessments.
Participants will have an MRI before or after having HD-tDCS intervention.
University of Michigan
Ann Arbor, Michigan, United States
RECRUITINGPercent change in precision force-tracking task
Squared distance (error) from the cursor to the target in precision force-tracking task, estimated as the root mean squared error (RMSE).
Time frame: Baseline and 24 hours after the third sessions are completed
Percentage change in the time to complete the nine-hole peg test (9-HPT)
9-hole peg test is a manual dexterity measure, estimated as the time required to complete the task (seconds).
Time frame: Baseline and 24 hours after the third sessions are completed
Percentage change in the mean choice reaction time
Mean reaction time for subjects responding in the 2-choice reaction time control task, for correct responses
Time frame: Baseline and 24 hours after the third sessions are completed
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