High-dose Dual Therapy and Minocycline-cotaining Quadruple Therapy for Helicobacter Pylori Infection

Inclusion Criteria: * Ability and willingness to participate in the study and to sign and give informed consent * Confirmed H. pylori infection Exclusion Criteria: * Pregnant and lactating women; * History of gastrointestinal malignancies; * History of previous subtotal gastrectomy; * Serious dysfunction of heart, liver, kidney, lung and other important organs and congenital diseases; Such as grade IV cardiac insufficiency, liver failure, uremia, respiratory failure, hemophilia, Wilson disease, etc; * History of hematological diseases * People who are allergic to drugs; * The guardian or patient refused to join the group; * Alcohol and / or drug abuse (addiction or dependence) or poor compliance judged by doctors; * No legal capacity or poor self-knowledge * administration of antibiotics, bismuth, antisecretory drugs, or Chinese herb medicine in the preceding 8 weeks