Background: Osteoarthritis (OA) is a prevalent form of arthritis worldwide. Intra-articular stromal vascular fraction (SVF) injections are a potential therapeutic option for patients with OA. This study aims to assess the effects of intra-articular SVF injections on knee OA. Methods: Ten patients with knee OA participated in this study. After being administered intra-articular SVF injections, their outcomes were evaluated using various questionnaires. MRI T2 mapping was conducted and compared before the intervention and 6 months after. All data underwent analysis using various tests.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
10
Adipose tissue was harvested using the Q-graft system (Human Med®) from the abdominal subcutaneous fat of patients under local anesthesia. After concentration and resuspension in normal saline, 5 mL of the SVF suspension was injected into the knee joint cavity under sterile conditions.
Fu Jen Catholic University Hospital
New Taipei City, Taiwan
The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
range from 0-96, with higher scores indicating greater OA-related disability
Time frame: Baseline and at 3 and 6 months post-intervention
Knee Injury and Osteoarthritis Outcome Score (KOOS)
5 items, ranging from 0-96, with higher scores indicating worse life quality related to OA
Time frame: Baseline and at 3 and 6 months post-intervention
Visual Analogue Scale (VAS)
range from 0-10, with higher scores indicating increased degree of pain
Time frame: Baseline and at 3 and 6 months post-intervention
Magnetic resonance imaging (MRI)
included T2 mapping
Time frame: Baseline and 6 months after the intervention
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