Clomiphene Citrate in Infertile Men With Idiopathic Oligoasthenozoospermia

Shakeela Ishrat50 enrolled

Overview

The goal of this clinical trial is to learn if drug clomiphene citrate improves sperm parameters in infertile men with idiopathic oligoasthenozoospermia. It will also learn about the safety of clomiphene citrate. The main questions it aims to answer are: * Does drug clomiphene citrate change sperm count and motility in infertile men with idiopathic oligoasthenozoospermia? * What medical problems do participants have when taking drug clomiphene citrate? Researchers will compare drug clomiphene citrate to a placebo (a look-alike substance that contains no drug) to see if drug clomiphene citrate works to treat idiopathic oligoasthenozoospermia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Infertility, Male

Interventions

Eligibility

Sex: MALEMin age: 25 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Infertile men * Idiopathic oligoasthenozoospermia (serum FSH and serum LH range was 2-7 IU/mL and serum testosterone level was \>300 ng/dl) Exclusion Criteria: * Azoospermia * Body mass index \<18 kg/m2 and \>30 kg/m2 * Any abnormality on genital examination and scrotal sonogram * History of genital diseases \& genital surgery * Medical and endocrine disorders like uncontrolled diabetes mellitus, severe kidney disease and liver insufficiency * Psycho-sexual abnormalities * Antioxidant supplements in previous 3 months * Smoking, drug, alcohol or substance abuse * History of chemotherapy or radiotherapy * Presence of any gross female factor abnormality

Outcomes

Primary Outcomes

Change from baseline in sperm motility at 12 weeks

Sperm motility was percentage of progressive \& non-progressive motility

Time frame: Baseline and 12 weeks

Change from baseline in sperm count at 12 weeks

Sperm count was in million per milliliter of semen