The purpose of this study is to compare the difference in the ability to detect hemodynamic abnormalities between invasive hemodynamic assessments performed at rest versus exercise, to assess the correlation between invasive and noninvasive (Doppler-derived) rest-exercise hemodynamic indices and to compare the association between indices of disease severity and hemodynamic abnormalities identified at rest versus exercise.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
200
Patient will undergo standard of care Cardiac Cath and in addition invasive CPET (Cardiopulmonary exercise testing) will be performed during the procedure.
Mayo Clinic
Rochester, Minnesota, United States
RECRUITINGChange in left ventricular end-systolic elastance from rest to peak exercise
Change in left ventricular end-systolic elastance will be measured in ΔmmHg/mL
Time frame: Baseline
Change in Left ventricular cardiac output from rest to peak exercise
Change in left ventricular cardiac output will be measured in ΔL/min
Time frame: Baseline
Change in systemic vascular resistance from rest to peak exercise
Change in systemic vascular resistance will be measured in ΔWoods Units
Time frame: Baseline
Change in right ventricular free-wall strain from rest to peak exercise
Change in right ventricular free-wall strain will be measured in Δ%
Time frame: Baseline
Change in right ventricular cardiac output from rest to peak exercise
Change in right ventricular cardiac output will be measured in ΔL/min
Time frame: Baseline
Change in pulmonary vascular resistance from rest to peak exercise
Change in pulmonary vascular resistance will be measured in ΔWoods Units
Time frame: Baseline
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