The goal of this clinical trial is to discuss the effects of physical activity on nutrition, inflammation, muscle metabolism, and the occurrence of cardiovascular and cerebrovascular events in patients with maintenance haemodialysis. The main question it aims to answer is: can exercise improve nutritional and inflammatory status, enhance muscle strength, and reduce the incidence of cardiovascular and cerebrovascular events in patients with maintenance haemodialysis. Researchers will compared active exercise group to conventional treatment group to see the impact of exercise on maintenance haemodialysis patients. Participants will: Choose low-intensity aerobic exercise workouts such as walking (no less than 8,000 steps per day) or jogging, swimming, Tai Chi, etc., according to their individual conditions, for no less than 30 minutes at a time, at least 3 times per week, and the intensity of the exercise should be based on an RPE score of 12 to 16.
RPE: Rating of Perceived Exertion. RPE scores of 12 to 16 indicate the need for increased respiratory rate and depth during exercise, the ability to engage in conversational exchanges, light sweating, and a feeling of slight fatigue without reaching a state of exhaustion.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
200
such as walking, jogging, swimming, Tai Chi, etc. It needs to be at a certain frequency and intensity
The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China
RECRUITINGMid-upper arm circumference of the non-internal fistula side（AC）
Measure the circumference of the non-internal fistula at the midpoint of the upper arm using a soft tape measure, in centimetres
Time frame: Baseline and half year, 1 year
triceps skin-fold thickness of the non-internal fistula side（TSF）
Measurement of the skinfold at the midpoint of the upper arm on the non-internal fistula side by using a skinfold thickness gauge, in centimetres
Time frame: Baseline and half year, 1 year
upper arm muscle circumference of the non-internal fistula side（AMC）
AMC（cm）= AC(cm) - 3.14 x TSF（cm）
Time frame: Baseline and half year, 1 year
calf circumference
Measure the calf circumference using a soft tape measure, in centimetres
Time frame: Baseline and half year, 1 year
grip strength
Using a grip strength meter, with the patient seated and gripping the handle firmly with the palm of the non-internal fistulae side, measure twice and record the maximum grip strength value
Time frame: Baseline and half year, 1 year
Incidence of cardiovascular and cerebrovascular events
Cardiovascular events include: heart failure episodes, sustained arrhythmias, myocardial infarction, and cerebrovascular events include: cerebral haemorrhage, cerebral infarction, transient ischaemic attack.
Time frame: 1 year
prealbumin
laboratory measurement indicators:prealbumin(g/L)
Time frame: Baseline and half year, 1 year
albumin
laboratory measurement indicators:albumin(g/L)
Time frame: Baseline and half year, 1 year
haemoglobin
laboratory measurement indicators:haemoglobin(g/L)
Time frame: Baseline and half year, 1 year
blood lipids
laboratory measurement indicators:triglycerides, cholesterol, low-density lipoprotein, high-density lipoprotein
Time frame: Baseline and half year, 1 year
c-reactive protein
laboratory measurement indicators:c-reactive protein(mg/L)
Time frame: Baseline and half year, 1 year
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