The study aims to assess the anti-aging and photoprotective efficacy of two active concentrations of a food supplement composed of Coriander Seed Oil (CSO).
A double blind, parallel groups, placebo-controlled study is carried out on 90 female subjects aged between 35 and 65 years old with visible Crow's feet wrinkles and mild to moderate skin slackness. The study foresees 56 days of products intake. Evaluations of the parameters under study are performed at baseline, after 14, 28 and 56 days of products consumption.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
99
The study foresees the intake of 1 capsule per day during 56 days
The study foresees the intake of 1 capsule per day during 56 days
The study foresees the intake of 1 capsule per day during 56 days
Complife Italia S.r.l
San Martino Siccomario, Italy
Skin profilometry
Primos 3D
Time frame: Baseline
Skin profilometry
Primos 3D
Time frame: 14 days
Skin profilometry
Primos 3D
Time frame: 28 days
Skin profilometry
Primos 3D
Time frame: 56 days
Skin elasticity
Cutometer
Time frame: Baseline
Skin elasticity
Cutometer
Time frame: 14 days
Skin elasticity
Cutometer
Time frame: 28 days
Skin elasticity
Cutometer
Time frame: 56 days
Transepidermal water loss
Tewameter
Time frame: Baseline
Transepidermal water loss
Tewameter
Time frame: 14 days
Transepidermal water loss
Tewameter
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Time frame: 28 days
Transepidermal water loss
Tewameter
Time frame: 56 days
Erythema index
Skin haemoglobin quantification by Mexameter 24h after UV exposure
Time frame: Baseline
Erythema index
Skin haemoglobin quantification by Mexameter 24h after UV exposure
Time frame: 28 days
Erythema index
Skin haemoglobin quantification by Mexameter 24h after UV exposure
Time frame: 56 days
Skin inflammation (subgroup of 20 subjects)
TNF-alpha quantification by Enzyme-Linked Immunosorbent Assay on skin stripping performed before and 24h after UV exposure
Time frame: Baseline
Skin inflammation (subgroup of 20 subjects)
TNF-alpha quantification by Enzyme-Linked Immunosorbent Assay on skin stripping performed before and 24h after UV exposure
Time frame: 56 days
Skin lipoxidation (subgroup of 20 subjects)
Malondialdehyde quantification by spectrophotometry on skin stripping performed before and 4h and 24h after UV exposure
Time frame: Baseline
Skin lipoxidation (subgroup of 20 subjects)
Malondialdehyde quantification by spectrophotometry on skin stripping performed before and 4h and 24h after UV exposure
Time frame: 56 days
Self-assessment of product efficacy
Questionnaire (10 questions with 4 possible answers : completely agree / agree / disagree / completely disagree)
Time frame: 56 days