Investigate the topical use of almond oil, almond oil augmented with 0.5% vitamin E, 0.025% tretinoin oil augmented with castor oil on the appearance of facial fine lines and wrinkles, pigmentation, hydration, trans-epidermal water loss, and sebum excretion rate.
The natural cosmetic market is a multi-billion dollar industry. Nutraceuticals and food-based cosmetics are a growing trend within dermatology. Almonds are a rich dietary source of a range of fatty acids, phytochemical polyphenols, and antioxidants. Our previous study was a double blinded study that compared almond consumption interventions to a calorie matched intervention over 16 weeks. The study determined that that there was a statistically significant 8.41% improvement in wrinkle severity in the women that received almond supplementation. This proposal aims to now understand how the topical application of almond oil may influence the appearance of wrinkles and facial tone in post-menopausal women. Almond oil is rich in fatty acids and alpha-tocopherol. Tocopherol inhibits melanogenesis in melanocytes and topical alpha tocopherol has been shown to improve skin antioxidants and hyperpigmentation. A challenge of almond oil is that it is prone to oxidation due to its high unsaturated fatty acid concentrations. However, tocopherol has also been shown to improve almond oil stability.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
90
1-2 Drops of randomized topical product will be applied on entire face nightly.
1-2 Drops of randomized topical product will be applied on entire face nightly.
1-2 Drops of randomized topical product will be applied on entire face nightly.
Integrative Research Institute
Sacramento, California, United States
RECRUITINGFacial wrinkles
Change in severity of wrinkles measured by photographic analysis (BTBP 3D Camera System)
Time frame: 16 Weeks
Changes in Pigment intensity through the use of high resolution photography (BTBP Clarity Pro)
Change in the appearance of facial pigmentation by high resolution photography (BTBP Clarity Pro) and measures intensity of facial pigmentation. Higher scores indicate darker pigmentation.
Time frame: 16 Weeks
Pigment intensity measured through SkinColorCatch.
Change in the appearance of facial pigmentation will be measured on both cheeks through the use of a handheld device known as the SkinColorCatch with quantitative output for pigment intensity.
Time frame: 16 Weeks
Changes in skin hydration
Change in skin hydration will be measured on both cheeks through the use of a non-invasive device known as the Moisturemeter.
Time frame: 16 Weeks
Sebum excretion rate
Measure of skin sebum via sebumeter
Time frame: 16 Weeks
Tolerability Assessment Questionnaire
A 6 question survey based on the self-assessment about the tolerability of the topical skin product. The scale ranges from 0-3 with 0 being the best outcome possible and with 3 being the worst. "0" as none, "1" as mild, "2" as moderate, or "3" as severe.
Time frame: 16 Weeks
Transepidermal water loss
Change in transepidermal water loss (TEWL) using the Vapometer
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Time frame: 16 Weeks