Neoadjuvant RC48 Plus Carboplatin for HER2-expressing Advanced Ovarian Cancer

Inclusion Criteria: \- General criteria: 1. Voluntarily consent to participate in the study and sign an informed consent form. 2. Age 18-75 years (at the time of signing consent). 3. Expected survival ≥ 12 months. 4. ECOG performance status 0 or 1. 5. Body weight must be \>30 kg. 6. Able to understand trial requirements and willing and able to adhere to trial and follow-up procedures. 7. Women of childbearing potential (defined as not having undergone surgical sterilization or not having naturally menstruated for at least 12 consecutive months) must agree to use effective contraception during the study treatment. \- Tumor-related criteria: 8. Newly diagnosed, histologically or cytologically confirmed FIGO stage III-IV high-grade serous ovarian cancer, fallopian tube cancer, or primary peritoneal cancer. 9. HER2 expression: including patients with HER2 immunohistochemistry (IHC) results of IHC 1+ or higher and gene amplification detected by ERBB2 testing. 10. Physical condition unsuitable for direct surgery or imaging or laparoscopic assessment indicating low likelihood of achieving complete resection through direct surgery. 11. Patients must have at least one measurable lesion according to RECIST v1.1 criteria (assessed by the investigator). \- Adequate organ function: Criteria met within 28 days prior to the first dose of Cycle 1: 12. Bone marrow function: Hemoglobin ≥ 90 g/dL Absolute neutrophil count ≥ 1.5 × 10\^9/L Platelet count ≥ 100 × 10\^9/L 13. Liver function (normal values as defined by the clinical trial center): Serum total bilirubin ≤ 1.5 times the upper limit of normal (ULN) In the absence of liver metastases, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) ≤ 2.5 × ULN; with liver metastases, ALT, AST, and ALP ≤ 5 × ULN 14. Renal function (normal values as defined by the clinical trial center): Serum creatinine ≤ 1.5 × ULN or creatinine clearance (CCr) ≥ 50 mL/min (Cockcroft-Gault formula) Urinalysis showing urinary protein ≥ 3+ should be followed by a 24-hour urine collection with 24-hour urinary protein \< 3.5 g 15. Coagulation function: International normalized ratio (INR) ≤ 1.5 or 2.5 (for patients receiving anticoagulation therapy) Activated partial thromboplastin time (APTT) ≤ 1.5 × ULN 16. Cardiac function: New York Heart Association (NYHA) classification \< Grade 3 Exclusion Criteria: \- Tumor-related criteria: 1. Histologic types of endometrioid carcinoma, clear cell carcinoma, mucinous carcinoma, or sarcomatoid tumors, including any mixed tumors with these types, or low-grade/borderline ovarian tumors. 2. Known active central nervous system (CNS) metastases and/or leptomeningeal disease. 3. Presence of pleural effusion, pericardial effusion, or ascites that cannot be controlled through drainage or other methods. \- Comorbidities and medical history: 4. Severe clinically significant active infections. 5. History of multiple sclerosis (MS) or other demyelinating diseases and/or Lambert-Eaton syndrome (paraneoplastic syndrome). 6. Significant clinically relevant heart disease, including but not limited to: 1. Myocardial infarction within ≤ 6 months prior to first dose; 2. Unstable angina; 3. Uncontrolled congestive heart failure (\> II grade); 4. Uncontrolled hypertension (≥ 3 grade per CTCAE criteria); 5. Uncontrolled arrhythmias. 7. Cerebrovascular accident (CVA), transient ischemic attack (TIA), or intracranial hemorrhage (e.g., brain hemorrhage, subarachnoid hemorrhage, or subdural hemorrhage) within 6 months prior to enrollment. 8. ECG showing clinically significant abnormal results. 9. History of clinically diagnosed and currently active non-infectious interstitial lung disease (ILD), including non-infectious pneumonia, pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, drug-induced pneumonitis, or other severe pulmonary diseases. 10. History of liver cirrhosis (Child-Pugh class C). 11. History of abdominal wall fistula, gastrointestinal perforation, or active gastrointestinal bleeding within 6 months prior to randomization. 12. Bleeding disorders or significant coagulation abnormalities (in the absence of anticoagulation). 13. Major surgery within 4 weeks prior to enrollment (except for exploratory procedures performed at other institutions). 14. Non-healing wounds, active ulcers, or fractures. 15. History of other primary malignancies, except for those with minimal risk of metastasis or death. \- Concurrent treatments: 16. Previous treatment with Vedicimab or other HER2-targeted therapies. 17. Prior anti-cancer treatment for ovarian cancer, including chemotherapy, immunotherapy, or targeted therapy; patients may receive concurrent hormone therapy (e.g., hormone replacement therapy) or bisphosphonates for non-cancer-related conditions. \- Other: 18. Known hypersensitivity to monoclonal antibody therapy, MMAE class drugs, or any component of the study drug. 19. Pregnant or breastfeeding women. 20. Investigator believes the subject has other severe systemic diseases or conditions that make participation in the clinical study inappropriate.