The goal of this prospective, randomized controlled study study is to investigate the efficacy and safety of propofol combined with different doses of esketamine (ESK) for anesthesia during loop electrosurgical excision procedure (LEEP).Ninety female patients undergoing LEEP were randomly allocated to three groups.It aims to answer :1.The effect of esketamine combined with propofol in respiration, circulation, etc,during LEEP. 2.The appropriate dosage of esketamine when combined with propofol in LEEP anesthesia.
To investigate the efficacy and safety of propofol combined with different doses of esketamine (ESK) for anesthesia during loop electrosurgical excision procedure (LEEP). Ninety female patients undergoing LEEP were randomly allocated to three groups: group P (2 mg/kg propofol + saline), group propofol + esketamine(PK)1 (1.5 mg/kg propofol + 0.5 mg/kg ESK), and group PK2 (1.5 mg/kg propofol + 0.25 mg/kg ESK). Parameters including mean arterial pressure (MAP), heart rate (HR), respiratory rate (RR), oxygen saturation (SPO2), and venous carbon dioxide (PvCO2) were recorded. Additionally, the need for supplemental propofol, jaw thrust maneuver or ventilation, postoperative awakening time, and adverse reactions were assessed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
90
Propofol was administered intravenously 2 mg/kg
intravenous injection of 0.5 mg/kg ESK followed by 1.5 mg/kg of propofol or intravenous injection of 0.25 mg/kg ESK followed by 1.5 mg/kg of propofol
The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China
Respiratory Rate
The respiratory rate (RR) was monitored from 3-lead ECG
Time frame: Immediately upon entering the operating room , 1 and 5 minutes after injection of anesthetics
Heart Rate
The heart rate (HR) was monitored using 3-lead ECG
Time frame: Immediately upon entering the operating room , 1 and 5 minutes after injection of anesthetics
Mean Arterial Pressure
The mean arterial pressure (MAP) was monitored using Noninvasive blood pressure monitor
Time frame: Immediately upon entering the operating room, 1 and 5 minutes after injection of anesthetics
Venous Carbon Dioxide
The venous carbon dioxide (PvCO2) was monitored using blood-gas analyzer
Time frame: Immediately upon entering the operating room and 5 minutes after injection of anesthetics
number of additional propofol usage
The number of additional propofol was recorded
Time frame: On the day of surgery, from the instant the anesthesia induction is completed to the instant completion of surgery,up to 10 minutes
postoperative awakening time
The postoperative awakening time (MOAA/S score \>4) was recorded
Time frame: On the day of surgery, from the instant completion of surgery to the moment the patient wakes up (when MOAA score >4),up to 10 minutes
number of jaw thrust maneuver or face mask ventilation
The number of jaw thrust maneuver or face mask ventilation was recorded
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Time frame: On the day of surgery, from the instant the anesthesia induction is completed to the instant completion of surgery,up to 10 minutes
incidences of postoperative vertigo, nausea, agitation and delirium
incidences of postoperative vertigo, nausea, agitation and delirium were recorded
Time frame: On the day of surgery,from the moment the patient wakes up (when MOAA score >4) to the moment the patient leaving the recovery room,up to 30minutes