This study aims to investigate the impact of antibiotic prophylaxis on reducing wound infection rates following open repair of primary elective groin hernias in high-risk patients.
This study will be a randomized controlled trial involving high-risk patients undergoing open repair of primary elective groin hernias. Participants will be randomized into two groups: one receiving antibiotic prophylaxis and the other serving as the control group. The study will assess the incidence of wound infections postoperatively in both groups to determine the effectiveness of antibiotic prophylaxis in lowering infection rates.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
200
* Medication: Cefazolin * Dosage: 1 gram * Administration Timing: A single dose will be administered preoperatively.
Aleppo University Hospital
Aleppo, Syria
RECRUITINGOverall Complication Rate
Overall complication rate; graded by the Clavien- Dindo complications classification system
Time frame: up to 30 days after the surgery.
Wound infection/ Surgical site infection
has been defined and classified as superficial incisional, deep incisional, and organ/ space\_ surgical site infection by the Centers for Disease Control and Prevention (CDC) (Anderson 2014; Ban 2017; Berríos-Torres 2017).
Time frame: up to 30 days after the surgery.
Mortality Rate
The measure of the number of deaths at the end of the study.
Time frame: up to 30 days after the surgery.
Hospital stay
In days: Number of days, patient in hospital since admission.
Time frame: up to 30 days after the surgery.
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