Dietary Intervention for Low Free Sugars in Children With Non-alcoholic Fatty Liver Disease

China Medical University, China146 enrolled

Overview

A 48-week dietary intervention program was conducted in children aged 5-14 years with a diagnosis of NAFLD, who were randomized into a low free sugar diet group and a regular diet group. The primary objective of this study is to determine whether a low free sugar dietary intervention program improves liver function, fasting glucose, fasting insulin, lipid profile and hepatic steatosis in children with NAFLD. The effects of the intervention will be analyzed and compared at weeks 12, 24 and 48.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

146

Conditions

NAFLD Low-free Sugar Dietary Child Obesity

Interventions

After baseline data collection, the intervention group received a 30-60 minute educational session with a dietitian and clinicians, including a health education prescription. Interventions occurred at weeks 1, 12 and 24, with routine evaluations of disease, diet, physical activity, and adherence. Follow-ups at 48 weeks assessed NAFLD extent, dietary profile, and health knowledge for both subjects and guardians.

Eligibility

Sex: ALLMin age: 5 YearsMax age: 14 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age: above 5 years old and below 14 years old; * Guardian's consent and signing of informed consent; * WHO growth and development curves as the reference standard, overweight is defined as BMI greater than or equal to the 85th percentile of the WHO growth curves for children, and obesity is defined as BMI greater than or equal to the 95th percentile of the WHO growth curves for children; * Liver imaging performance meets the diagnostic criteria of diffuse fatty liver. Exclusion Criteria: * Age \<5 years or \>14 years; * Previous history of alcohol consumption; * Non-cooperation with the study, inability to comply with the study treatment or study visit. * Past or active hepatitis B virus infection; * Past or active hepatitis C virus infection; * Chronic or acute liver failure; * Cholestasis; * Hepatomegaly; * Cystic fibrosis; * α1-antitrypsin deficiency; * Autoimmune hepatitis; * Tyrosinemia; * Galactosemia or any recognized liver disease, any physical condition deemed by a physician to be unable to complete the trial. Physical Condition.

Outcomes

Primary Outcomes

NAFLD

NAFLD was diagnosed using liver ultrasonography with a Phillip IU Elite color Doppler ultrasound after a fasting period to reduce gastrointestinal interference.