Crohn's disease (CD) is an incurable chronic inflammatory disorder of the gastrointestinal tract. Ulcerative colitis (UC) is an idiopathic, chronic, inflammatory disease affecting the colon. This study will assess the (long-term) effectiveness and safety of upadacitinib in real-world clinical practice in adult participants with moderate to severe ulcerative colitis (UC) and crohn's disease (CD). Upadacitinib is an approved drug for treating ulcerative colitis (UC) and Crohn's disease (CD). Approximately 280 participants who are prescribed Upadacitinib by their physician in accordance with local label will be enrolled in 8 sites across Belgium. Participants will receive upadacitinib as prescribed by their physician according to their routine clinical practice and local label. Participants will be followed for up to 3 years. There is expected to be no additional burden for participants in this trial. Participants will attend regular visits during the study at a hospital or clinic according to their routine clinical practice
Study Type
OBSERVATIONAL
Enrollment
280
Imelda Ziekenhuis /ID# 268631
Bonheiden, Antwerpen, Belgium
RECRUITINGUniversite Libre de Bruxelles - Hopital Erasme /ID# 268632
Anderlecht, Brussels Capital, Belgium
RECRUITINGCHU de Liège /ID# 267209
Liège, Liege, Belgium
RECRUITINGUZ Gent /ID# 268630
Ghent, Oost-Vlaanderen, Belgium
RECRUITINGVitaz /Id# 268637
Sint-Niklaas, Oost-Vlaanderen, Belgium
RECRUITINGAZ Groeninge /ID# 268638
Kortrijk, West-Vlaanderen, Belgium
RECRUITINGGroupe Sante CHC - Clinique du MontLegia /ID# 268662
Liège, Belgium
RECRUITINGPercentage of Participants Achieving Clinical Remission as per Partial Adapted Mayo Subscores for Ulcerative Colitis
Clinical remission is defined as: stool frequency (SF) score \< = 1 and not greater than baseline and Rectal bleeding (RB) score = 0
Time frame: Up to approximately 52 weeks
Percentage of Participants Achieving Clinical Remission as per Patient Reported Outcome (PRO2) for Crohn's Disease
Clinical remission is defined as stool frequency (SF) score \< =3 and not worse than baseline and Abdominal Pain (AP) score \< =1 and not worse than baseline
Time frame: Up to approximately 52 weeks
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