Cardiac Anesthesia Registry Including Biosignal Database for Prognostication of Postoperative Renal Outcome

N/ANot Yet RecruitingNCT06581289

Yonsei University10,000 enrolled

Overview

AKI(Acute Kidney Injury) is a common complication after cardiac surgery which is associated with increased mortality and morbidity. Collecting perioperative biosignal data and studying their association with renal outcomes can help improve kidney injury, mortality, and morbidity in cardiac surgical patients. Furthermore, the occurrence of AKI, length of hospital stay, and recovery of renal function after discharge are closely associated with the development of chronic kidney disease (CKD). Therefore, regular monitoring of renal function and related indicators in cardiac surgical patients can help improve long-term outcomes.

Study Type

OBSERVATIONAL

Enrollment

10,000

Conditions

Cardiac Anaesthesia

Eligibility

Sex: ALLMin age: 19 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 19 years and older scheduled for cardiac surgery using CPB Exclusion Criteria: * emergency operation, the patient is foreigner or illiterate and unable to read the consent form

Locations (1)

Severance Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

post-operative AKI incidence within 1 week after cardiac surgery with CPB

The definition of AKI refers to Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury.

Time frame: within first 7 days after surgery

Secondary Outcomes

MAKE 30 (Major adverse kidney event within 30 days)

death, starting dialysis, or decrease in eGFR of 25 % or more within 30 days after surgery

Time frame: within 30 days after surgery

MAKE 90 (Major Adverse kidney event within 90 days)

death, starting dialysis, or decrease in eGFR of 25 % or more within 90 days after surgery

Time frame: within 90 days after surgery

incidence of CKD (chronic kidney disease) within 1 year

at least one of the following criteria is met, with structural or functional abnormalities of the kidney persisting for at least 3 months within 1 year * urine albumin/creatinine ratio ≥ 30 mg/g * abnormality in urine sediment test or persistent hematuria * renal structural abnormalities found in image study * eGFR \< 60 ml/min/1.73m2 (GFR category G3a-G5)

Time frame: within 1 year after surgery

1 year mortality

death due to any cause within 1 year

Time frame: within 1 year after surgery

in-hospital mortality

death which occurs during the hospitalization

Time frame: from day of hospitalization for surgery until discharge after surgery 1year