The goal of this observational study is to profile changes in DNA methylation of circulating CD4+ T and CD8+ T cells from healthy young to aged with diagnosis of HFpEF, a particular phenotype of HF which is highly prevalent in aging. The main question it aims to answer is: -Do DNA methylation biomarkers help us to understand the role of inflammation in HFpEF during aging? Our goal is to provide a simple large-scale panel of epigenetic-sensitive biomarkers useful in aged patients with HF in the early natural history of the disease (HFpEF).
Study Type
OBSERVATIONAL
Enrollment
150
Measure of genomic regions with differentially methylated profiles and differentially expressed protein
University of Campania Luigi Vanvitelli
Naples, No States Available, Italy
Number of differentially methylated positions and regions as assessed by RRBS
We will identify a panel of positions and regions of the genome which are differentially methylated using as measure diff.meth more than or minor than 2 and p minor than 0.05
Time frame: 6 months
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