* The aim of this study is comparative between: 1. Intra-radicular cryotherapy using cold anti-inflammatory {ketorolac tromethamine at 2-5C}. 2. Intra-radicular final flush anti-inflammatory {ketorolac tromethamine at room temperature}. * In terms of: C. Level of post-operative pain {POP} using a visual analog scale {VAS}. D. Level of substance P in periapical fluid will be analyzed by enzyme-linked immunosorbent assay (ELISA) kit. Outcomes : * Primary outcomes: Level of Post-operative pain. * Secondary outcomes: Level of substance P expression
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
60
* Intra- radicular anti-inflammatory {ketorolac tromethamine at room temperature}. * Intra- radicular cold anti-inflammatory {ketorolac tromethamine at 2-5C}.
Faculty of Dentistry, Ain Shams University
Cairo, Egypt
Level of Post-operative pain.
measure intensity of post operative pain using visual analogue scale that was represented by a 100 mm horizontal ruler with no number markings other than a 0 at one end and a 10 at the other end. The following categories of postoperative pain levels were used to assess pain: 0 indicating no pain, mild pain (1-3), moderate pain (4-7) and severe pain (8-10)
Time frame: 12 hours post operative
Level of Post-operative pain.
measure intensity of post operative pain using visual analogue scale that was represented by a 100 mm horizontal ruler with no number markings other than a 0 at one end and a 10 at the other end. The following categories of postoperative pain levels were used to assess pain: 0 indicating no pain, mild pain (1-3), moderate pain (4-7) and severe pain (8-10)
Time frame: 24 hours post operative
Level of Post-operative pain.
measure intensity of post operative pain using visual analogue scale that was represented by a 100 mm horizontal ruler with no number markings other than a 0 at one end and a 10 at the other end. The following categories of postoperative pain levels were used to assess pain: 0 indicating no pain, mild pain (1-3), moderate pain (4-7) and severe pain (8-10)
Time frame: 48 hours post operative
Level of substance P expression.
Quantification of substance P will be done using an ELISA test from peri-radicular fluid swab.
Time frame: 15 minutes following access cavity preparation.
Level of substance P expression.
Quantification of substance P will be done using an ELISA test from peri-radicular fluid swab.
Time frame: 30 minutes following access cavity preparation.
Level of substance P expression.
Quantification of substance P will be done using an ELISA test from peri-radicular fluid swab.
Time frame: Immediately prior to obturation
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.