Interest of Lidocaine in Children with Upper Airway Infection Undergoing General Anesthesia

Tunis University102 enrolled

Overview

The goal of this clinical trial is to determine whether intravenous (IV) lidocaine reduces the incidence of perioperative respiratory complications (PRCs) in children with upper respiratory tract infections undergoing general anesthesia. The study will also evaluate the safety of IV lidocaine in this population. The main questions it aims to answer are: 1. Does IV lidocaine lower the incidence of perioperative respiratory complications (e.g., laryngospasm, cough, desaturation) compared to a placebo? 2. What are the side effects associated with the administration of IV lidocaine in these children? Researchers will compare IV lidocaine to a placebo to assess its effectiveness in reducing PRCs.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

102

Conditions

Upper Respiratory Tract Infections Perioperative Respiratory Complications

Interventions

Eligibility

Sex: ALLMin age: 12 MonthsMax age: 14 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Children aged 1 to 14 years. * American Society of Anesthesiologists (ASA) Physical Status Classification I, II, or III. * Scheduled or urgent surgery or radiological exploration under general anesthesia. * Upper respiratory tract infection (URTI) symptoms present for less than 15 days. Exclusion Criteria: * Refusal of participation by parents. * Children on long-term corticosteroid or bronchodilator therapy. * Contraindications to the use of lidocaine or other drugs used in the protocol. * Patients who did not adhere to the study protocol.

Outcomes

Primary Outcomes

Incidence of Perioperative Respiratory Complications

Measure the occurrence of perioperative respiratory complications (e.g., laryngospasm, cough, desaturation, bronchospasm) from the induction of anesthesia until discharge from the recovery room.

Time frame: Within the first 2 hours post-operation.

Secondary Outcomes

Incidence of Side Effects Related to IV Lidocaine

Measure the occurrence of side effects such as nausea, vomiting, cardiac or neurological toxicity, and signs of anaphylaxis following the administration of IV lidocaine.

Time frame: Within the first 24 hours post-operation.