Thyroid-associated ophthalmopathy (TAO) is an organ-specific autoimmune disease closely related to thyroid disease, which leads the incidence of orbital disease in adults and is the most common cause of diffuse toxic goiter (Graves disease, GD). The clinical manifestations of TAO are complex and varied. In severe cases, it may seriously impair visual function, affect daily life, and even cause corneal ulceration, perforation, and blindness. Therefore, a reasonable and effective treatment plan should be chosen according to the degree of TAO. The aim of this clinical study is to: 1. Found characteristic changes from baseline to the end of treatment. 2. Identify characteristic changes associated with treatment response. 3. Construct a multimodal and multiparameter prediction model by characteristic changes.
Study Type
OBSERVATIONAL
Enrollment
500
Percentage of participants with overall response
Overall response
Time frame: 1 week after the end of treatment
Percentage of participants with overall response
Overall response
Time frame: 24 weeks after the end of treatment
Percentage of participants with overall response
Overall response
Time frame: 52 weeks after the end of treatment
Percentage of participants with overall response
Overall response
Time frame: 104 weeks after the end of treatment
Incidence and characterization of nonserious treatment emergent adverse events (TEAEs) during the treament
Time frame: during the treament
Change of Serum TRAb from baseline
including TRAb (IU/l)
Time frame: 52 weeks after the end of treatment
Change of Serum T3,T4 level from baseline
inculde T3 (nmol/L), T4 (nmol/L)
Time frame: 52 weeks after the end of treatment
Change of Serum lipid parameter
including TG (mmol/L), TC (mmol/L), HDL (mmol/L), LDL (mmol/L)
Time frame: 52 weeks after the end of treatment
Change of Serum TSH level from baseline
including TSH (mIU/L)
Time frame: 52 weeks after the end of treatment
Change of Serum FT3, FT4 level from baseline
including FT3 (pmol/L), FT4(pmol/L)
Time frame: 104 weeks after the end of treatment
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.