Growing evidence has shown that exclusive enteral nutrition (EEN) plays an important role in the preoperative optimization for patients with Crohn's disease (CD). However, the efficacy and safety of different types of enteral feeds including semi-elemental and polymeric enteral nutrition on CD have not been investigated. The aim of this study was to compare the role of semi-elemental and polymeric enteral nutrition on CD.
Growing evidence has shown that exclusive enteral nutrition (EEN) plays an important role in the preoperative optimization for patients with Crohn's disease (CD). However, the efficacy and safety of different types of enteral feeds including semi-elemental and polymeric enteral nutrition on CD have not been investigated. The aim of this study was to compare the role of semi-elemental and polymeric enteral nutrition on CD. The primary outcome: the reduction rate of CRP/ALB after exclusive enteral nutrition in Crohn's disease. The other outcomes: (1) the changes in Crohn's disease activity index; (2) the tolerance of enteral nutrition; (3) the changes in body mass index; (4) postoperative complications and the incidence of stoma; (5) the rate of surgery; (6) other adverse reactions.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
304
CD patients requiring bowel resection and preoperative EEN were randomized to receive peptison liquid for 6 weeks.
CD patients requiring bowel resection and preoperative EEN were randomized to receive enteral nutritional suspension for 6 weeks.
Wei Zhou
Hangzhou, Zhejiang, China
The change of CRP/ALB level
The ratio of C-reactive protein to albumin level changed after exclusive enteral nutrition.
Time frame: 6 weeks
BMI
The BMI level changed after exclusive enteral nutrition.
Time frame: 6 weeks
CDAI
Crohn's disease activity index, from 0 to 600, the higher index shows more serious of CD.
Time frame: 6 weeks
postoperative complications
The incidence of postoperative complications in two groups.
Time frame: 6 weeks
adverse reaction
The incidence of adverse reaction during exclusive enteral nutrition.
Time frame: 6 weeks
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