A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease

Cohort Legend: Cohort 1: Inflammatory Bowel Diseases - Crohn's Disease or Ulcerative Colitis, Cohort 2: Celiac Disease, Cohort 3: Ankylosing spondylitis or non-radiographic axial spondyloarthritis (nr-axSpA), Cohort 4: Multiple Sclerosis, Cohort 5: Scleroderma, Cohort 6: Systemic Sclerosis with pulmonary involvement, Cohort 7: Other Autoimmune Disease, Cohort 8: Apparent Evolving Autoimmune Disease, Cohort 9: Frozen Cryopreserved Inclusion Criteria: * Study cohorts 1,2,3,4,5,6,7,8.9: Known or suspected diagnosis, with subsequent diagnostic confirmation, of one of the following cohorts associated with the following autoimmune diseases: * Inflammatory Bowel Diseases - Crohn's Disease or ulcerative colitis * Celiac disease * Ankylosing spondylitis or Non radiographic axial spondyloarthritis (nr-axSpA) * Multiple sclerosis * Scleroderma * Systemic sclerosis with pulmonary involvement * Other autoimmune disease (as agreed between Investigator and Sponsor) * Apparent evolving autoimmune disease * Frozen cryopreserved * Age equal or greater than 18 years at time of informed consent. * Ability to understand and willingness to sign an informed consent document when informed consent is required by an ethical review board. * On disease-modifying treatments that are not known to be directly T cell toxic. Such treatments are allowed and include: * Non-steroidal anti-inflammatory drugs including aspirin, ibuprofen, acetaminophen, celecoxib, indomethacin, diclofenac, etodolac, naproxen, meloxicam, sulindac, nabumetone amongst others. * Tumor necrosis factor alpha (TNF-alpha) antagonists including infliximab (Remicade), adalimumab (Humira), certolizumab pegol (Cimzia), etanercept (Enbrel), golimumab (Simponi) and biosimilar drugs with the same generic name. * Interleukin-12/23 antagonists including ustekinumab (Stelara) and risankizumab-rzaa (Skyrizi) * Alpha-4-integrin antagonists including vedolizumab (Entyvio), natalizumab (Tysabri) * Interleukin-17 inhibitors including secukinumab (Cosentyx), ixekizumab (Taltz) * Recombinant interferon beta * CD20 antagonists including rituximab (Rituxan), ocrelizumab (Ocrevus), ofatumumab (Kesimpta) * Oral fumarates including dimethyl fumarate (Tecfidera), diroximel fumarate (Vumerity), monomethyl fumarate (Bafiertam) * Oral sphingosine 1-phosphate receptor (S1PR) modulators including fingolimod (Gilenya), siponimod (Mayzent), ozanimod (Zeposia), ponesimod (Ponvory) * Oral glatiramer acetate (copolymer 1; Copaxone) * Patient is an appropriate candidate for a procedure to obtain a biopsy, tissue samples or biologic materials during a clinically indicated procedure where it is expected that excess materials could be used for research OR * In the opinion of the clinical investigator, a patient is an appropriate, low-risk candidate for a research only procedure to obtain a biopsy, tissue samples or biologic materials. Exclusion Criteria: * On treatment with drugs that are known to be T cell toxic and cannot be held for at least 4 weeks or longer. The following treatments are not allowed except in designated cohorts when approved by Sponsor: * Glucocorticoids including prednisone, methylprednisolone (Solu-medrol), budesonide (Entocort), hydrocortisone (Solu-cortef), dexamethasone (Decadron), betamethasone (Betaject) * Sulfasalazine (Azulfidine) * Aminosalicylates including mesalamine/ mesalazine (Asacol, Pentasa). * Thiopurines including azathioprine (Imuran) and 6-mercaptopurine (Purixan) * Systemic JAK inhibitors including tofacitinib (Xeljanz), abrocitinib (Cibinqo), baricitinib (Olumiant), upadacitinib (Rinvoq) * CD52 inhibitors including alemtuzumab (Campath) * Methotrexate * Cladribine * Teriflunomide (Aubagio) * Concurrent disease or condition that would make the patient inappropriate for study participation, or any serious medical or psychiatric disorder that would interfere with the subject's safety. * Dementia, altered mental status, or any psychiatric condition that would prohibit the understanding or rendering of informed consent. * Patients receiving research biopsy procedures will not have a history of serious or life-threatening allergic reaction to local anesthetics (i.e., lidocaine, xylocaine), if local anesthetic is required for the procedure or to medications used for sedation during a procedure. * Pregnant or nursing women are excluded because there may be unanticipated adverse events and increased risk to both mother and fetus in the setting of local anesthetic or study procedures. * Any other medical or psychiatric condition, which in the opinion of the patient's treating clinician, would make participation in this protocol unreasonably hazardous for the patient.