The purpose of the study is to better understand the effects of cannabis in relation to mental and physical states including its relationship with mood, cognition, perception including the experience of temperature and pain, and heart rate. We expect that participants will be in this research study for approximately one week. The total amount of time that participants will spend completing study tasks will be about 2.5 hours across two separate in-person visits.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
166
Participants are assigned to warm water temperature.
Participants are assigned to cold water temperature and are video recorded.
University of Colorado at Boulder
Boulder, Colorado, United States
RECRUITINGBlood Cortisol Levels
Cortisol levels are measured in blood.
Time frame: Pre-Use/Pre-Water Task, 20 minutes Post-Use, 40 minutes Post-Use
Cannabis Used
Grams of product used is calculated. Product is measured before and after use to measure how much was used.
Time frame: Immediate Post-Use
Blood Endocannabinoid Levels
Blood levels of AEA are measured.
Time frame: Pre-Use/Pre-Water Task, 20 minutes Post-Use
Heart Rate
Participant HR is measured via pulse oximeter.
Time frame: Pre-Use/Pre-Water Task, Pre-Use/Post-Water Task, 20 minutes Post-Use
Social Anxiety
Social Interaction Anxiety Scale (SIAS). 20 item survey, questions are answered on scale of 0 (not at all) to 4 (extremely), with higher scores indicating higher social anxiety. Questions are summed, with higher overall scores indicating higher social anxiety.
Time frame: Pre-Use/Pre-Water Task
Inhibitory Control
Go/No-go Task. Participants are asked to complete a cognitive task where they see the text "Go" or "No go" during different trials. When they see "Go", they need to push a button within 2 seconds. When they see "No-go", they need to make sure they do not press the button (for 2 seconds). This is a measure of impulsivity.
Time frame: Baseline
Stress
Stress Subscale of Depression and Anxiety Stress Scale measures stress. On scale from 0 (does not apply to me at all) to 3 (apply to me very much or most of the time). Higher scores indicate higher stress levels.
Time frame: Pre-Use/Pre-Water Task
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Blood cannabinoid levels
THC and CBD blood levels are measured.
Time frame: Pre-Use/Pre-Water Task, 20 minutes Post-Use
Current Pain
Internal scale/measure, measured from 0 (no pain) to 10 (worst pain imaginable). Participants report current pain on this self-report scale.
Time frame: Pre-Use/Pre-Water Task, Pre-Use/Post-Water Task, 20 minutes Post-Use, 40 minutes Post-Use
Mood
Profile of Mood States (POMS). Focus on the stress, anxiety, tension, and relaxation questions (combined for a tension/anxiety subscale). Questions are on a scale 1 (not at all) to 5 (extremely). Scores are summed, with higher scores indicating more tension/anxiety.
Time frame: Pre-Use/Pre-Water Task, Pre-Use/Post-Water Task, 20 minutes Post-Use, 40 minutes Post-Use