Really few data published to date on the passage of CBD into breast milk. The investigators known that 17.5 percent of the French human being between 18 and 34 years old consume CBD and among this, nearly half are women. None official French data to say how many French breastfeeding mothers consume CBD. CBD is a legal, psychoactive but not psychoaddictive substance. CBD's pharmacokinetic and pharmacodynamics make us fear that CBD could easily go through mother's milk. No published data available on possible effect in breast-fed child, not even on possible biological passage in breast-fed child. The aim of his study is to evaluate the passage of CBD in blood and milk at different moments of the breastfeeding (mothers) and its possible found in the infants'urine.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
60
Determination of delta 9-tetrahydrocannabinol (THC) and its metabolites , and of cannabidiol and its metabolites in blood and breasts-milk by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Realization of THC/CBD ratio; qualitative research in mother's and breast-fed child's urine for the presence of cannabinoids (THC, CBD and its metabolites).
CHU Orléans
Orléans, France
RECRUITINGTheoretical dose of CBD received by the breastfed child over 24 hours
Theoretical dose of CBD received by the breastfed child over 24 hours by measuring blood and milk concentrations of CBD during postpartum visits.
Time frame: Day 2 postpartum
Theoretical dose of CBD received by the breastfed child over 24 hours
Theoretical dose of CBD received by the breastfed child over 24 hours by measuring blood and milk concentrations of CBD during postpartum visits.
Time frame: Day 21 postpartum
Theoretical dose of CBD received by the breastfed child over 24 hours
Theoretical dose of CBD received by the breastfed child over 24 hours by measuring blood and milk concentrations of CBD during postpartum visits.
Time frame: Day 42 postpartum
Theoretical dose of CBD received by the breastfed child over 24 hours
Theoretical dose of CBD received by the breastfed child over 24 hours by measuring blood and milk concentrations of CBD during postpartum visits.
Time frame: Month 3 postpartum
Theoretical dose of CBD received by the breastfed child over 24 hours
Theoretical dose of CBD received by the breastfed child over 24 hours by measuring blood and milk concentrations of CBD during postpartum visits.
Time frame: Month 4 postpartum
Theoretical dose of CBD received by the breastfed child over 24 hours
Theoretical dose of CBD received by the breastfed child over 24 hours by measuring blood and milk concentrations of CBD during postpartum visits.
Time frame: Month 6 postpartum
Theoretical dose of CBD received by the breastfed child over 24 hours
Theoretical dose of CBD received by the breastfed child over 24 hours by measuring blood and milk concentrations of CBD during postpartum visits.
Time frame: Month 9 postpartum
Theoretical dose of CBD received by the breastfed child over 24 hours
Theoretical dose of CBD received by the breastfed child over 24 hours by measuring blood and milk concentrations of CBD during postpartum visits.
Time frame: Month 12 postpartum
Concentration of CBD in maternal blood
Time frame: Day 2 postpartum
Concentration of CBD in maternal blood
Time frame: Day 21 postpartum
Concentration of CBD in maternal blood
Time frame: Day 42 postpartum
Concentration of CBD in maternal blood
Time frame: Month 3 postpartum
Concentration of CBD in maternal blood
Time frame: Month 4 postpartum
Concentration of CBD in maternal blood
Time frame: Month 6 postpartum
Concentration of CBD in maternal blood
Time frame: Month 9 postpartum
Concentration of CBD in maternal blood
Time frame: Month 12 postpartum
Concentration of CBD metabolites in maternal blood
Time frame: Day 2 postpartum
Concentration of CBD metabolites in maternal blood
Time frame: Day 21 postpartum
Concentration of CBD metabolites in maternal blood
Time frame: Month 3 postpartum
Concentration of CBD metabolites in maternal blood
Time frame: Month 4 postpartum
Concentration of CBD metabolites in maternal blood
Time frame: Month 6 postpartum
Marie-Philippe LEBOUCHARD-MAAKAROUN, Dr
CONTACT
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Concentration of CBD metabolites in maternal blood
Time frame: Month 9 postpartum
Concentration of CBD metabolites in maternal blood
Time frame: Month 12 postpartum
Concentration of CBD in breast-milk
Time frame: Day 2 postpartum
Concentration of CBD in breast-milk
Time frame: Day 21 postpartum
Concentration of CBD in breast-milk
Time frame: Day 42 postpartum
Concentration of CBD in breast-milk
Time frame: Month 3 postpartum
Concentration of CBD in breast-milk
Time frame: Month 4 postpartum
Concentration of CBD in breast-milk
Time frame: Month 6 postpartum
Concentration of CBD in breast-milk
Time frame: Month 9 postpartum
Concentration of CBD in breast-milk
Time frame: Month 12 postpartum
THC concentrations in mother's blood
Time frame: Day 2 postpartum
THC concentrations in mother's blood
Time frame: Day 21 postpartum
THC concentrations in mother's blood
Time frame: Day 42 postpartum
THC concentrations in mother's blood
Time frame: Month 3 postpartum
THC concentrations in mother's blood
Time frame: Month 4 postpartum
THC concentrations in mother's blood
Time frame: Month 6 postpartum
THC concentrations in mother's blood
Time frame: Month 9 postpartum
THC concentrations in mother's blood
Time frame: Month 12 postpartum
THC concentrations in breast milk
Time frame: Day 2 postpartum
THC concentrations in breast milk
Time frame: Day 21 postpartum
THC concentrations in breast milk
Time frame: Day 42 postpartum
THC concentrations in breast milk
Time frame: Month 3 postpartum
THC concentrations in breast milk
Time frame: Month 4 postpartum
THC concentrations in breast milk
Time frame: Month 6 postpartum
THC concentrations in breast milk
Time frame: Month 9 postpartum
THC concentrations in breast milk
Time frame: Month 12 postpartum
Percentage of breastfeeding mother's with CBD metabolites in urine
Time frame: Day 2 postpartum
Percentage of breastfeeding mother's with CBD metabolites in urine
Time frame: Day 21 postpartum
Percentage of breastfeeding mother's with CBD metabolites in urine
Time frame: Day 42 postpartum
Percentage of breastfeeding mother's with CBD metabolites in urine
Time frame: Month 3 postpartum
Percentage of breastfeeding mother's with CBD metabolites in urine
Time frame: Month 4 postpartum
Percentage of breastfeeding mother's with CBD metabolites in urine
Time frame: Month 6 postpartum
Percentage of breastfeeding mother's with CBD metabolites in urine
Time frame: Month 9 postpartum
THC/CBD ratio
Time frame: Day 2 postpartum
Percentage of breastfeeding child with CBD in urine
Time frame: Day 2 postpartum
Percentage of breastfeeding child with CBD in urine
Time frame: Day 21 postpartum
Percentage of breastfeeding child with CBD in urine
Time frame: Day 42 postpartum
Percentage of breastfeeding child with CBD in urine
Time frame: Month 3 postpartum
Percentage of breastfeeding child with CBD in urine
Time frame: Month 4 postpartum
Percentage of breastfeeding child with CBD in urine
Time frame: Month 6 postpartum
Percentage of breastfeeding child with CBD in urine
Time frame: Month 9 postpartum
Percentage of breastfeeding child with CBD metabolites in urine
Time frame: Day 2 postpartum
Percentage of breastfeeding child with CBD metabolites in urine
Time frame: Day 21 postpartum
Percentage of breastfeeding child with CBD metabolites in urine
Time frame: Day 42 postpartum
Percentage of breastfeeding child with CBD metabolites in urine
Time frame: Month 3 postpartum
Percentage of breastfeeding child with CBD metabolites in urine
Time frame: Month 4 postpartum
Percentage of breastfeeding child with CBD metabolites in urine
Time frame: Month 6 postpartum
Percentage of breastfeeding child with CBD metabolites in urine
Time frame: Month 9 postpartum
impact of ethnicity
Time frame: Day 2 postpartum
Percentage of breastfeeding mother's with CBD in urine
Time frame: Day 2 postpartum
Percentage of breastfeeding mother's with CBD in urine
Time frame: Day 21 postpartum
Percentage of breastfeeding mother's with CBD in urine
Time frame: Day 42 postpartum
Percentage of breastfeeding mother's with CBD in urine
Time frame: Month 4 postpartum
Percentage of breastfeeding mother's with CBD in urine
Time frame: Month 6 postpartum
Percentage of breastfeeding mother's with CBD metabolites in urine
Time frame: Month 12 postpartum
Percentage of breastfeeding mother's with CBD in urine
Time frame: Month 12 postpartum
Percentage of breastfeeding mother's with CBD in urine
Time frame: Month 3 postpartum
Percentage of breastfeeding child with CBD metabolites in urine
Time frame: Month 12 postpartum
Percentage of breastfeeding mother's with THC in urine
Time frame: Day 2 postpartum
Percentage of breastfeeding mother's with THC in urine
Time frame: Day 21 postpartum
Percentage of breastfeeding mother's with THC in urine
Time frame: Day 42 postpartum
Percentage of breastfeeding mother's with THC in urine
Time frame: Month 3 postpartum
Percentage of breastfeeding mother's with THC in urine
Time frame: Month 4 postpartum
Percentage of breastfeeding mother's with THC in urine
Time frame: Month 6 postpartum
Percentage of breastfeeding mother's with THC in urine
Time frame: Month 9 postpartum
Percentage of breastfeeding mother's with THC in urine
Time frame: Month 12 postpartum