Harmonized and Pooled Database, Named PRIME.

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)3,270 enrolled

Overview

We merged the dataset of three large observational studies of invasive ventilation in critically ill patients.

PRIME contains the individual patient data of 3 large observational studies of ventilation, 'PRactice of VENTilation in critically ill patients without ARDS' (PRoVENT), 'PRactice of VENTilation in critically ill patients in Middle-income Countries' (PRoVENT-iMiC) and 'Extubation strategies and in neuro-intensive care unit patients and associations with outcomes' (ENIO).

Study Type

OBSERVATIONAL

Enrollment

3,270

Conditions

Invasive Ventilation

Interventions

Invasive ventilationOTHER

Invasive ventilation and respiratory support

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 Years

Medical Language ↔ Plain English

All patients in the PRIME database are eligible for participation in the initial analysis presented here. We will exclude patients receiving ventilation fir another reason than acute brain injury.

Locations (1)

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Amsterdam, Netherlands

Outcomes

Primary Outcomes

ICU morality

any mortality occurred during ICU stay

Time frame: ICU stay, anticipated average 15 days

Secondary Outcomes

Mechanical Power

All variables or parameters recorded from the ventilator, when the patient is under mechanical ventilation, to calculate the mechanical power (calculated in Joule/minute)

Time frame: During the first 7 days of invasive ventilation

Data from ClinicalTrials.gov

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