Efficacy and Safety of Intravitreal Injection of Bevacizumab with and Without Oral Curcumin

Inclusion Criteria: Patients with center-involving macular edema with macular center thickness more than 300 microns in OCT 2-Patients who did not receive intravitreal bevacizumab in the last 3 months and intravitreal corticosteroids in the last 6 months. 3- The amount of BCVA should not be \<20/400. 4-Consent to participate in the study Exclusion Criteria: 1. Other retinal diseases except for DME and macular edema due to other causes including uveitis, epiretinal membrane, central retinal vein occlusion, and... 2. Existence of proliferative diabetic retinopathy and patients with a history of vitrectomy 3. Patients with glaucoma, vitreous hemorrhage, age-related macular degeneration (ARMD) 4. Media opacities that limit the interpretation of diagnostic tests 5. Surgery or procedure 3 months before starting treatment 6. Pregnancy or breastfeeding 7. History of allergy to curcumin 8. Use of warfarin 9. Changing the patient's clinical diagnosis or the need for surgical interventions in the course of the disease 10. Change in the patient's general health condition 11. Absence of patient referrals 12. Lack of consent to continue treatment and follow-up