Loss of Y Chromosome in Aortic Stenosis

University of Virginia200 enrolled

Overview

The most common heart valve disease in humans is aortic stenosis which is a critical narrowing of the valve through which the heart has to pump blood to the rest of the body. This condition occurs in 2-3% of adults over 65 years of age and when it progresses to a severe stage leads to heart failure and need for valve replacement procedures (including surgery and catheter-based replacement). Aortic stenosis has a strong male predominance. The purpose of this study is to evaluate whether loss of Y-chromosome from circulating blood cells in males, which has been associated with TGF-beta-related fibrosis of other organs, is associated with the development of aortic stenosis.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Aortic Stenosis

Interventions

Blood analysis for loss-of-Y chromosomeDIAGNOSTIC_TEST

Analysis for the percentage of circulating leukocytes with loss-of-y chromosome

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * Aortic stenosis (valve area \<1.5cm2) Exclusion Criteria: * Bicuspid aortic valve * History of radiation to chest * Inflammatory (autoimmune, rheumatologic) disease associated with aortic stenosis * Active cancer

Outcomes

Primary Outcomes

Loss of Y chromosome

This is a cross-sectional case-control study where the outcome measure is the percentage of circulating cells that have loss-of-Y chromosome

Time frame: 1 day

Central Contacts

Jonathan R Lindner, MD

CONTACT

434 2979442 jlindner@virginia.edu

Bethany Gholson