Cannabis Edibles and Simulated Driving

Centre for Addiction and Mental Health52 enrolled

Overview

The goal of this human laboratory experiment is to determine the acute and residual effects of a range of doses of orally administered cannabis edibles on driving simulator performance in people who use cannabis recreationally. Four conditions will be tested: placebo, low dose, medium dose and high dose. Driving performance will be tested objectively using a driving simulator during a number of pre-programmed driving scenarios. The investigators will test the hypothesis that driving performance on a high-fidelity driving simulator will decrease with increasing doses of cannabis. Secondary objectives will: * Determine the acute and residual (24 hour) cognitive, behavioural, and physiological effects of a range of doses of orally administered cannabis edibles on subjective effects, cognitive tests, verbal memory, and mood. * Examine how the concentration of THC in blood and oral fluids correlates with driving simulator performance, as well as cognitive, behavioural, and physiological measures. Cannabinoid levels in blood, urine and oral fluids will be measured at baseline and over a 5 hour period following drug exposure. The investigators will examine the relationship between cannabinoid levels and performance measures in this time frame. * Explore potential biomarkers of acute exposure to cannabis edibles by analyzing the following: circulating cell-free mtDNA (ccf-mtDNA), endocannabinoids, and metabolic biomarkers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

TRIPLE

Enrollment

Conditions

Cannabis

Eligibility

Sex: ALLMin age: 19 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Provides written and informed consent * Stated the willingness to comply with all study procedures * Recreational use of oral, vaped, smoked or edible cannabis (at least one day/week) and cannabis edibles (at least one day/month) confirmed by self-report and urine screening (i.e., positive THC result in point-of-care screening or Clinical Laboratory assay) * Males and females aged 19 to 45 years * Has held a class G license (or equivalent from another jurisdiction) for at least 12 months * Willing to abstain from using cannabis for 72 hours prior to each practice or test session * Willing to abstain from alcohol for 48 hours prior to each practice or test session, and to abstain from all other drugs not medically required for the duration of the study (beginning 48 hours prior to the practice session) * Lives within a radius that costs less than about $60 per taxi ride * Able to consume the quantity of candies and drive the driving simulator as determined by a practice session * A negative urine pregnancy test for those with childbearing potential * Use of appropriate contraception for those with childbearing potential Exclusion Criteria: * Diagnosis of severe medical or psychiatric condition (e.g., diagnosis of a severe mood or anxiety disorder, based on self-report * Meets criteria for current or lifetime alcohol or other substance use disorder (DSM-5), except tobacco use disorder and caffeine use disorder * Regular user of medication that may affect cognitive functioning and/or driver performance (e.g. ADHD medication, benzodiazepines, stimulants, opioids) * Regular user of illicit substances * Personal or family history of schizophrenia or other psychotic disorder * Pregnant, looking to become pregnant, or breastfeeding * Concomitant therapy with sedative-hypnotics or other psychoactive drugs * Severe laboratory abnormalities that could create safety issues based on the judgement of the Principal Investigator * Cardiovascular or cerebrovascular disease * Severe renal or liver disease * Participation in another clinical or non-therapeutic study in the past month

Outcomes

Primary Outcomes

Standard Deviation of Lateral Position (SDLP)

The driving simulator will objectively record SDLP during a number of pre-programmed driving scenarios.

Time frame: Before cannabis exposure; 2 and 5 hours after cannabis exposure (repeated each session for 4 sessions). Also repeated on the test for residual effects, approximately 24 hours after dosing.

Secondary Outcomes

Mean Speed (MS)

The driving simulator will objectively record MS during a number of pre-programmed driving scenarios.

Reaction Time (RT)

The driving simulator will objectively record RT during a number of pre-programmed driving scenarios.

Standard Deviation of Speed (SDS)

The driving simulator will objectively record SDS during a number of pre-programmed driving scenarios.

Blood concentrations of Δ9-tetrahydrocannabinol (THC), 11-hydroxy-Δ9-tetrahydrocannabinol (OH-THC), and 11-Nor-9-carboxy-Δ9-tetrahydrocannabinol (THC-COOH)

Used to assess THC and metabolite concentrations (ng/mL) in blood.

Oral fluid concentrations of Δ9-tetrahydrocannabinol (THC), 11-hydroxy-Δ9-tetrahydrocannabinol (OH-THC), and 11-Nor-9-carboxy-Δ9-tetrahydrocannabinol (THC-COOH) and point-of-care detection of cannabinoids

Used to assess THC and metabolite concentrations (ng/mL) in oral fluid.

Heart Rate

Heart rate (bpm) will be measured.

Time frame: Before cannabis exposure; 0, 30, 60, 90 minutes and 2, 3, 4 and 5 hours after cannabis exposure (repeated each session for 4 sessions). Also repeated approximately 24 hours after dosing.

Blood Pressure

Systolic and diastolic blood pressure (mmHg) will be measured.

Time frame: Before cannabis exposure; 0, 30, 60, 90 minutes and 2, 3, 4 and 5 hours after cannabis exposure (repeated each session for 4 sessions). Also repeated approximately 24 hours after dosing.

Temperature

Temperature (degrees Celsius) will be measured.

Time frame: Before cannabis exposure; 0, 30, 60, 90 minutes and 2, 3, 4 and 5 hours after cannabis exposure (repeated each session for 4 sessions). Also repeated approximately 24 hours after dosing.

Visual Analog Scale (VAS)

Used to assess subjective effects of cannabis on a sliding scale of 0 (not at all) to 100 (maximum effect).

Time frame: Before cannabis exposure; 0, 30, 60, 90 minutes and 2, 3, 4 and 5 hours after cannabis exposure (repeated each session for 4 sessions). Also repeated approximately 24 hours after dosing.

Addiction Research Centre Inventory (ARCI)

Used to assess subjective effects of cannabis.

Profile of Mood States (POMS)

Used to assess subjective effects of cannabis.

Verbal Free Recall Task

Used to assess the impact of cannabis on verbal learning and memory.

Blood Concentrations of mtDNA

Used to assess concentrations of mtDNA.

Blood Concentrations Endocannabinoids

Used to assess concentrations of endocannabinoids.

Cannabis Edibles and Simulated Driving

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes