Fluid Responsiveness in Posterior Fossa Tumor Resection: PPV and CVP Guidance

N/AActive Not RecruitingNCT06595667

Chiang Mai University50 enrolled

Overview

To answer the question: What are the differences in intraoperative fluid administration volumes between PPV and CVP-guided strategies during posterior fossa tumor resection in the park bench position?

Prospective RCT is conducted to compared the amount of fluid volume in adult patients undergoing posterior fossa surgery in park bench position.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Posterior Fossa Tumor Brain Tumor Adult

Interventions

Pulse pressure variationPROCEDURE

Fluid administration during posterior fossa surgery in the parkbench position is guided by the PPV value.

Central venous pressurePROCEDURE

Fluid administration during posterior fossa surgery in the parkbench position is guided by the CVP value.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Adult patients aged 18 years and above 2. American Society of Anesthesiologists (ASA) I and II 3. Diagnosis of posterior fossa tumor requiring surgical resection in the park bench position, under general anesthesia at our hospital 4. Willing to participate in the study Exclusion Criteria: 1. Arrhythmia 2. Significant cardiac diseases 3. Chronic obstructive airway disease 4. Elevated intra-abdominal pressure 5. Tumors prone to precipitate diabetes insipidus 6. Peripheral vascular disease 7. Pulmonary hypertension 8. Patients in sepsis

Locations (1)

Chiang Mai University

Chiang Mai, Chiang Mai, Thailand

Outcomes

Primary Outcomes

Total intraoperative fluid administration volumes during surgery

fluid and blood and blood volume transfusion during surgery

Time frame: during surgery

Secondary Outcomes

vital signs

blood pressure both systolic and diastolic pressure

Time frame: during surgery, the data will be recorded every 5 minutes throughout the procedure

vital signs

blood pressure both systolic and diastolic pressure

Time frame: during the admission in neurosurgical ICU up to 3 days after surgery

time to extubation

to be able to succesfully extubated, count time period of using ventilator

Time frame: 48 hours after surgery at the neurosurgical intensive care unit

Data from ClinicalTrials.gov

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