Clinical Study of Intestinal Barrier Dysfunction After Gastrointestinal Surgery

N/ANot Yet RecruitingNCT06596070

The Second Affiliated Hospital of Kunming Medical University180 enrolled

Overview

The goal of this observational study is to explore the clinical influences associated with the development of intestinal barrier dysfunction in patients undergoing gastrointestinal surgery. The main question it aims to answer is:What clinical factors increase the probability of developing intestinal barrier dysfunction in patients after gastrointestinal surgery?

Study Type

OBSERVATIONAL

Enrollment

180

Conditions

Intestinal Barrier Dysfunction

Interventions

No intervention was carried outOTHER

This study is an observational study and no intervention was performed on the patients.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * men or women aged 18-80 years * expected feasible abdominal surgical treatment (partial gastrectomy, colorectal resection) * no preoperative intestinal barrier dysfunction * patients voluntarily participated in this study and signed an informed consent form. Exclusion Criteria: * Patients or their families refused to participate in this study * chronic inflammatory diseases (e.g. inflammatory bowel disease, chronic hepatitis, chronic pancreatitis, chronic peptic ulcer, etc.) * history of antibiotic administration in the last 2 weeks * severe cognitive impairment and other inability to cooperate preoperative neoadjuvant radiotherapy * combined with severe hepatic, renal, and cardiac insufficiency patients.

Outcomes

Primary Outcomes

operating time

Record the patient\'s surgical time

Time frame: During surgery

Secondary Outcomes

nutritional status

Patients were assessed for risk of malnutrition by the Nutritional Risk Screening Scale (NRS-2002). A score of ≥3 indicated that the patient was at risk of malnutrition.

Time frame: Preoperative

bowel habit

The patient was asked whether there were increased frequency of stool, changes in stool characteristics, constipation and other conditions before surgery

Time frame: Preoperative

Surgical Procedures

Record whether the patient underwent laparoscopic surgery or open surgery

Time frame: During surgery

hemorrhage

Record the patient\'s intraoperative bleeding volume

Time frame: During surgery

Albumin

Record the patient\'s albumin levels before and 24 hours after surgery

Time frame: Preoperative and postoperative 24 hours

Infection indicators

Record the values of PCT, IL-6, and CRP of patients before and 24 hours after surgery

Time frame: Preoperative and postoperative 24 hours

age

Time frame: Preoperative

gender

Central Contacts

weiming Li

CONTACT

13114225597 liweiming49@163.com

Data from ClinicalTrials.gov

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