Spasticity and rigidity are common symptoms of central nervous system injuries, such as spinal cord injury and Parkinson's disease, and result in distinct patterns of increased resistance during passive joint movements. Spasticity is characterized by a velocity-dependent increase in stretch reflexes, accompanied by exaggerated tendon responses, while rigidity is marked by consistent resistance throughout the range of motion, traditionally considered independent of stretch velocity. However, recent studies suggest that rigidity may also be influenced by stretch velocity. This study aims to investigate muscle tone by examining spasticity, rigidity, and normal muscle function through neural and biomechanical changes. Standard clinical tools, such as the Modified Ashworth Scale and Unified Parkinson's Disease Rating Scale, along with additional assessments like the Myoton and Post-Activation Depression (PAD), will be employed.
Spasticity and rigidity are common symptoms resulting from central nervous system injuries (e.g., spinal cord injury and Parkinson's disease). During passive joint movement, spasticity and rigidity manifest as two distinct patterns of increased resistance. Spasticity is a type of hypertonia characterized by a stretch reflex that increases with speed, accompanied by exaggerated tendon reflexes. Rigidity, on the other hand, is another form of hypertonia, where resistance increases during passive movement and remains consistent throughout the range of motion. The degree of rigidity is traditionally considered independent of stretch velocity, which is one of the key differences from spasticity. However, recent studies have found that rigidity may also increase with stretch velocity. Despite attempts to distinguish different types of hypertonia based on stretch velocity, these efforts have largely been unsuccessful. Many factors influence muscle tone, which can be broadly categorized into changes in neural and biomechanical properties. The Modified Ashworth Scale and the Unified Parkinson's Disease Rating Scale are the most commonly used clinical tools for assessing spasticity and rigidity. Additionally, devices such as the Myoton or laboratory parameters like Post-Activation Depression (PAD) are also used for assessment.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
45
Continuous passive motion device (CPM) of ankle at 1HZ(60rpm) for 10 repetitions
Continuous passive motion device (CPM) of ankle 0.25HZ (15rpm) for 10 repetitions
Chang Gung University
Taoyuan District, Taiwan
RECRUITINGH-reflex Amplitude
The peak-to-peak amplitude of the H-reflex measured in the soleus muscle to assess spinal motor neuron excitability. Unit: Millivolts (mV)
Time frame: Before CPM, immediately after CPM
M-wave Amplitude
The peak-to-peak amplitude of the M-wave recorded in the soleus muscle to assess peripheral motor neuron excitability and muscle response. Unit: Millivolts (mV)
Time frame: Before CPM, immediately after CPM
Level of Post-Activation Depression (PAD) of the H-reflex.
The H-reflex will be elicited by electrical stimulation of the tibial nerve (or other motor nerves), and PAD will be assessed by measuring the reduction in H-reflex amplitude following a series of repetitive stimuli. The amplitude of the H-reflex after repeated stimulation will be compared to the baseline single stimulus.
Time frame: Before CPM, immediately after CPM
H/M ratio
The H/M ratio is calculated by dividing the amplitude of the H-reflex by the amplitude of the M-wave.
Time frame: Before CPM, immediately after CPM
Muscle Tone (Frequency, Hz)
This parameter measures the natural oscillation frequency of the muscle in response. It reflects the muscle's state of tension or readiness
Time frame: Before CPM, immediately after CPM
Elasticity (Dynamic Stiffness, N/m)
Elasticity, measured in Newtons per meter, reflects the muscle's ability to return to its original shape after being deformed by the impulse
Time frame: Before CPM, immediately after CPM
Stiffness (Decay, ms)
This parameter quantifies the rate at which the muscle returns to its initial state after the impulse, indicating the muscle's stiffness.
Time frame: Before CPM, immediately after CPM
Mechanical Stress (Creep, s) and Relaxation (S)
These parameters measure the time it takes for muscle tissue to adapt to a sustained force (creep) and the time it takes for the muscle to return to a relaxed state after removing the force (relaxation)
Time frame: Before CPM, immediately after CPM
Plantar foot pressure distribution and peak pressure
Foot pressure will be measured using a pressure sensors during ankle movement.
Time frame: Measured continuously during CPM
M-wave Latency
The time from the onset of electrical stimulation to the onset of the M-wave response in the soleus muscle, used to assess changes in peripheral nerve conduction velocity. Unit: Milliseconds (ms)
Time frame: Before CPM, immediately after CPM
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