To assess the plasma pharmacokinetics, the routes extent of elimination, and the metabolites of TS-172 after single oral dose of \[14C\] TS-172 in Japanese healthy male subjects. To assess the safety of single oral dose of \[14C\] TS-172 in Japanese healthy male subjects.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
6
Subjects will receive single dose of about 30 mg of TS-172 containing 1 MBq \[14C\]TS-172 as an oral solution
Taisho Pharmaceutical Co., Ltd selected site
Tokyo, Japan
Radioactivity concentration in whole blood and plasma
Time frame: Up to 240 hours after dosing
Calculation of cumulative urinary and fecal recovery of total radioactivity, and calculation of mass balance as a sum of the percentages of total radioactivity recovered in urine and faeces
Time frame: Up to 240 hours after dosing
Concentration of unchanged form and its major metabolites in plasma
Time frame: Up to 240 hours after dosing
Percentage of unchanged form and metabolites to total radioactivity in plasma
Time frame: Up to 240 hours after dosing
Percentage of unchanged form and metabolites to total radioactivity in urine and faeces
Time frame: Up to 240 hours after dosing
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