Personalized Digital Training Intervention to Reduce Inflammation by Correcting Pathological Movement Patterns in Pre-stage Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction

Inclusion Criteria: * Signed written informed consent * Adult subjects between 18 to 50 years old at the time of screening * Primary ACL reconstruction within a maximum of 6 months after a unilateral ACL injury * Complete baseline assessment between 8 and 12 weeks after ACL reconstruction Exclusion Criteria: * Significant trauma to a weight-bearing joint within 12 months prior to study initiation (excluding the ACL injury) * Previous surgeries on the study knee (except for the ACL reconstruction) * Signs of knee OA as defined by the OARSI-Joint Space Narrowing (JSN) Score of two or more (standing AP x-ray) * Physical activity level: Tegner activity score before injury of 0-2 (very low activity) or 8-10 (very high activity) * Body mass index ≥ 30 kg/m2; * Inflammatory arthropathies; * Immunosuppression due to illness or medication; * Sepsis or hemostasis disorders; * Severe uncontrolled inflammatory disease or autoimmune disease (e.g., ulcerative colitis, Crohn's disease, etc.); * Having malignancy and undergoing treatment including chemotherapy, radiotherapy, or immunotherapy; * Contraindications for MRI, including pacemakers, defibrillators, metal implants, pregnancy, sensorineural hearing loss above 30 dB, tinnitus and claustrophobia * Unable to freely give their informed consent (e.g., individuals under legal guardianship). * Currently enrolled in or has not yet completed a period of at least 5 times as the half-life time of the drug used in the previous trial since ending other investigational device or drug trial(s) * Patients who are dependent on the sponsor, investigator, or study site; * Pregnant or breast-feeding women or women of childbearing potential not protected by an effective contraceptive method of birth control (defined as pearl index \< 1); * Any form of substance abuse, psychiatric disorder, or other condition that, in the opinion of the Investigator, may invalidate communication with the Investigator and/or designated study personnel; * Patients who are committed to an institution by virtue of an order issued by either the judicial or the administrative authorities;