Serum Uromodulin and DN Systematic Review and Meta Analysis

Inclusion Criteria: * Studies were included if they met the following criteria: 1. serum level of uromodulin was determined; 2. the samples were enrolled from diabetic patients; 3. mean ± SD was reported for uromodulin between patients with and without DN; 4. the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN was determined Exclusion Criteria: * Studies were excluded according to the following criteria: 1. duplicate studies; 2. review articles; 3. non original research articles; 4. studies with insufficient data to extract; 5. non-human research; 6. studies that determined urine level of uromodulin.