Myocardial Bridging in Obstructive Hypertrophic Cardiomyopathy

Chinese Academy of Medical Sciences, Fuwai Hospital968 enrolled

Overview

This study investigated the impact of myocardial bridging (MB) and its characteristics on preoperative atrial fibrillation and survival in patients with obstructive hypertrophic cardiomyopathy (oHCM). We recruited 968 consecutive patients with oHCM who underwent myectomy at our institution between January 2015 and December 2019, including 144 patients with MB and 824 patients without MB. All patients received angiography before surgery. The diagnosis of preoperative atrial fibrillation was based on 12-lead electrocardiography, 24-hour Holter electrocardiography, or in-hospital electrocardiogram monitoring, which was extracted from patients' medical records. Surgical details and follow-up data were also collected.

Study Type

OBSERVATIONAL

Enrollment

968

Conditions

Myocardial Bridging Obstructive Hypertrophic Cardiomyopathy Atrial Fibrillation (AF)

Interventions

Patients had an MB with \>75% compression degree would receive coronary artery bypass grafting, and those who underwent unroofing may had a depth of MB \< 5mm (whether deal with these MB with a depth \<5mm depends on the surgeon and the period time of patients received a surgery).

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria:I(i) age ≥ 18 years and (ii) diagnosis of oHCM based on clinical and echocardiographic evaluation. \- Exclusion Criteria: (i) a history of heart surgery (ii) Patients who had coronary atherosclerosis or myocardial infraction; (iii) Patients who had no angiography records. \-

Outcomes

Primary Outcomes

All-cause death

Any death occurred one month after discharge

Time frame: One month after discharge

Secondary Outcomes

New-onset AF

Patients did not have AF before surgery, and AF occurred one month after discharge.

Time frame: One month after discharge.

Composite endpoints

Composite endpoints including all-cause death, new-onset AF, and readmission due to heart failure, stroke, and other cardiovascular events (such as myocardial infarction, arrhythmia).