This is a prospective, open-label, multicentric study designed to correlate the dose delivered to the hippocampus with declarative memory deficits 2 years after radiotherapy treatment in a paediatric population who had received brain irradiation between the ages of 4 and 12 for a brain tumour. In order to meet this objective, several neuropsychological assessments consisting of parental questionnaires and cognitive tests will be carried out during the course of the study, at the following two stages: * A 1st assessment at patient inclusion, i.e. 2 years after the end of radiotherapy treatment, * And a second assessment 2 years after patient inclusion, i.e. 4 years after the end of radiotherapy treatment. A retrospective assessment of the patient's neurocognitive level 1 year before the diagnosis of the disease will also be carried out at inclusion, with the parents completing a questionnaire specifically designed for the trial. In addition, patients who have received their radiotherapy treatment at the IUCT-O will be offered participation in the ancillary imaging study. If the parents and the patient agree, multimodal MRI scans specific to the study (without injection of contrast) will be performed at inclusion and 2 years after inclusion. Imaging and radiotherapy data will be collected in parallel using the PediaRT software used in current practice (collection of radiotherapy dosimetric data as well as standard MRI examinations pre-operatively, post-operatively, and at the 2-year and 4-year follow-up). 130 patients will be included in this study.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
130
Several neuropsychological assessments were carried out during the study (at inclusion and 2 years after inclusion), consisting of : * parental questionnaires (standard questionnaires and questionnaires specifically drawn up for the trial). The aim of these questionnaires will be to assess the patient's neurocognitive level at different times (before and after radiotherapy treatment). * patient cognitive tests (½ day face-to-face consultation/assessment with a neuropsychologist specialising in paediatrics, followed by a 30-minute telephone call). Only for patients having received their radiotherapy treatment at the IUCT-O: a multimodal MRI specific to the study (without injection of contrast product) may be performed at inclusion and 2 years after inclusion.
CHU Angers
Angers, France
NOT_YET_RECRUITINGCHU de Bordeaux
Bordeaux, France
RECRUITINGCentre François Baclesse
Caen, France
NOT_YET_RECRUITINGCentre Georges François Leclerc
Dijon, France
NOT_YET_RECRUITINGCentre Oscar Lambret
Lille, France
NOT_YET_RECRUITINGCentre Léon Bérard
Lyon, France
RECRUITINGAPHM - Hôpital la Timone
Marseille, France
NOT_YET_RECRUITINGInstitut du Cancer de Montpellier
Montpellier, France
NOT_YET_RECRUITINGInstitut Curie
Paris, France
NOT_YET_RECRUITINGCentre Eugène Marquis
Rennes, France
NOT_YET_RECRUITING...and 5 more locations
A deficit of the declarative memory will be defined by a standard score of the Children' Memory Scale (CMS) ≤ 5
Time frame: 24 months for each patient
Declarative memory will be assessed using the adapted EPIREAL test.
Time frame: 24 months for each patient
Declarative memory will be assessed by the autobiographical memory question.
Time frame: 24 months for each patient
The deficit of the procedural memory will be defined by a score of less than or equal to 10/20 on the last 20 trials (out of 50) of the probabilistic classification task.
Time frame: 24 months for each patient
The deficit of the procedural memory will be defined by a specific learning score less than or equal to zero of the adapted serial reaction time task (SRTT).
Time frame: 24 months for each patient
Working memory deficit will be defined if at least one of the two subtests (Number memory (WISC-V) and Spatial memory (WNV)) shows a deficit.
For each subtest, a deficit will be defined respectively by a standard score ≤ 5 and a percentile rank ≤ 5.
Time frame: 24 months for each patient
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