Comparison of SPECT/CT Perfusion and Volumetric CT Volume

Central Hospital, Nancy, France50 enrolled

Overview

The main aim of this study is to show that single photon emission tomography/Computer tomography (SPECT/CT) is a reliable examination to predict postoperative pulmonary function after segmentectomy, by comparing this predicted function to that measured at 1 and 6 months.

Lung cancer has a high prevalence, incidence and mortality in France and worldwide. Surgical treatment, possible only at an early stage, improves the prognosis of patients. In addition, the increasing accessibility of chest CT scans allows early detection and monitoring of small pulmonary nodules. As a result, more conservative surgical techniques are becoming increasingly important, including segmentectomy. Among patients for whom it is indicated, the preoperative assessment involves the evaluation of pulmonary function and the prediction of postoperative pulmonary function in order to validate the feasibility of surgery. To do this, several methods have been described: anatomical methods (segment counting), radiological imaging methods (CT, DECT, perfusion MRI), and nuclear imaging methods (planar perfusion and/or ventilation pulmonary scintigraphy, SPECT pulmonary perfusion scintigraphy), some of which are hybrid (SPECT/CT). The use of SPECT/CT to predict postoperative pulmonary function is routinely practiced, and its reliability, accuracy, and concordance with measured postoperative pulmonary function are well demonstrated for pneumectomy and lobectomy. For more conservative surgeries, the data in the literature remain uncertain. However, being able to predict pulmonary function is essential, both to justify the feasibility of the intervention, but also to target the most fragile patients and intensify their postoperative respiratory rehabilitation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Lung Cancer (NSCLC)

Interventions

lung scintigraphyOTHER

Use the SPECT/CT to predict pulmonary function

Eligibility

Sex: ALLMin age: 18 YearsMax age: 95 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Person having received full information on the organization of the research and not having opposed the exploitation of this data * Patients having benefited from a single or multiple segmentectomy within the thoracic surgery department of the CHRU of Nancy during the period April 2021 to June 2023 * Patients having a complete pre-operative assessment (SPECT/CT, volumetric CT and EFR) * Patients having 2 post-operative assessments (respiratory functional exploration (EFR) at approximately 1 month post-operatively and 6 months post-operatively). Exclusion Criteria: * Patients who underwent more extensive surgery (lobectomy, pneumectomy) or less extensive surgery (wedge). * Patient who did not have a complete preoperative assessment (SPECT/CT or volumetric CT or missing respiratory functional exploration EFR). * Patient who did not have a complete postoperative assessment (missing respiratory functional exploration EFR at 6 months). NB: the absence of respiratory functional exploration EFR at 1 month postoperatively is not an exclusion criterion

Locations (1)

CHRU of NANCY

Vandœuvre-lès-Nancy, France

Outcomes

Primary Outcomes

To demonstrate that SPECT/CT is a reliable examination for predicting postoperative pulmonary function after segmentectomy, by comparing this predicted function to that measured at 1 and 6 months.

Predicted postoperative pulmonary function using SPECT/CT (% perfusion participation of the removed segment(s)). Postoperative pulmonary function measured at 1 month Postoperative pulmonary function measured at 6 months

Time frame: 7 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.