Nitazoxanide for Treatment of Cryptosporidium in Children

Inclusion Criteria: * tests positive for Cryptosporidium by stool point-of-care test, with or without active diarrhea * family plans on remaining in the area for next 6 months Exclusion Criteria: * history of hypersensitivity to nitazoxanide. * taking warfarin. Tizoxanide, the metabolite of nitazoxanide is highly bound to plasma proteins and may compete with binding sites of other highly plasma bound drugs with narrow therapeutic indices, including warfarin. * history of renal insufficiency or a baseline serum creatinine = 40 µmol/L. Renal clearance of the drug has not been studied. * history of hepatic dysfunction or serum aspartate aminotransferase (AST) ; * 50 U/L, serum alanine transaminase (ATL) ; * 50 U/L, or serum bilirubin ; * 23 µmol/L. Hepatic clearance of the drug has not been studied.