To define the prevalence, duration and severity of propofol-associated euphoria in patients undergoing painless gastrointestinal endoscopy and to explore the independent influencing factors by means of a single-center, cross-sectional clinical research study
Study Type
OBSERVATIONAL
Enrollment
986
Northern Jiangsu People's Hospital
Yangzhou, Jiangsu, China
Incidence of propofol-related euphoria
Subjects were asked in person or through telephone follow-up, "To what extent do you think you are feeling pleasure and euphoria now?". The NRS is a numerical rating scale (NRS) that represents feelings of euphoria on a scale of 0-10, with 0 being no feelings of euphoria at all and 10 being the strongest feelings of euphoria.
Time frame: preoperatively , within half an hour after the operation, postoperative days 1 ,3 and 7
Severity of propofol-related euphoria
Subjects were asked in person or via telephone follow-up, "Has your pleasant, euphoric mood changed now compared to before surgery?" , using the Likert questionnaire score (5-Point Likert Scale, Likert): 0 indicates that the mood is significantly worse than before; 1 indicates that the mood is mildly worse than before; 2 indicates that there is no change in euphoria; 3 indicates that there is a mild euphoria; and 4 indicates that there is a markedly euphoric mood.
Time frame: preoperatively , within half an hour after the operation, postoperative days 1,3 and 7
Duration of propofol-related euphoria
Postoperatively, subjects were asked about changes in mood compared to baseline values by the same method, and their duration was confirmed.
Time frame: within half an hour after the operation, postoperative days 1 ,3 and 7
Anxiety level
Face-to-face questioning or follow-up via telephone, questioning the disease to record the anxiety level, using the NRS rating, which represents the anxiety level through ten numbers from 0-10, with 0 being no anxiety at all and 10 being the most intense anxiety.
Time frame: preoperatively , within half an hour after the operation, postoperative days 1,3 and 7
Subject satisfaction with the quality of perioperative anesthesia
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Assessment method: in person or through telephone follow-up, the subjects were asked to measure their satisfaction with the intraoperative and postoperative resuscitation periods as well as the entire period after discharge, which was rated by NRS, and satisfaction was represented by ten numbers from 0-10, with 0 being unsatisfactory and 10 being the most satisfactory.
Time frame: at postoperative days 1 after the subject had recovered from all adverse events, if the subject did not have a perioperative adverse event
Content of Memory of Intraoperative Dreams
If the subject was able to recall the dream, the dream was rated on a Likert questionnaire: 1. the mood of the dream: 1-5, 1 as very sad, 5 as very happy; 2. the extent to which the dream was remembered; 1-5, 1 as not remembering at all, 5 as remembering at all: 3. the sounds in the dream: 1-5, 1 as not at all, 5 as all of them; 4. the movements in the dream: 1-5 1 for not at all, 5 for all of them. Calculate the sum of the Dreamland Likert questionnaire scores.
Time frame: Within half an hour after the operation
The number of times of sleep in the 72h postoperative period
The number of times of sleep were asked and recorded during the 72h period after painless gastrointestinal endoscopy by telephone follow-up.
Time frame: Postoperative days 1 and 3
the duration of each sleep in the 72h postoperative period
The duration of each sleep were asked and recorded during the 72h period after painless gastrointestinal endoscopy by telephone follow-up.
Time frame: Postoperative days 1 and 3
the quality of sleep each time in the 72h postoperative period
Ask for and record the quality of sleep each time through telephone follow-ups The quality of sleep was categorized into five grades of "very good, good, fair, bad, and very bad" . Each grade corresponds to 5, 4, 3, 2, and 1 points.
Time frame: Postoperative days 1 and 3
Perioperative adverse events
In-person questioning or telephone follow-up, using the Common Terminology Criteria for Adverse Events (CTCAE), version 5.0, to determine perioperative adverse events and assess the severity of the adverse events against the feedback collected from the subjects.
Time frame: Within half an hour after the operation, postoperative days 1,3 and 7. If the adverse events had not disappeared by T7d, telephone follow-up was conducted every 3d thereafter until the adverse events were resolved.