Relationships Between Exercise and Appetite in Women With Loss of Control Eating

Ohio University26 enrolled

Overview

This pilot study is a first step in looking at the relationship between exercise and appetite in women with loss of control eating.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Eating Disorders Binge-Eating Disorder Bulimia Nervosa

Interventions

RestBEHAVIORAL

Participants will eat breakfast but abstain from exercise

Fed ExerciseBEHAVIORAL

Participants will eat breakfast and engage in 30 minutes of physical activity at 75% of their personal V02max.

Fasted ExerciseBEHAVIORAL

Participants will engage in 30 minutes of physical activity at their personal 75% V02max after abstaining from breakfast.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Engage in loss of control eating at least 12 times in the last three months * Clinically significant eating disorder-related impairment (CIA \> 15) * Taking hormonal contraception * Minimum VO2max of 50th percentile for age and sex assigned at birth * Be willing to eat study-provided foods * Likes chocolate (at least 6/10 on 10 point scale) Exclusion Criteria: * BMI \&lt; 18.5 kgm/2 * Medical conditions that affect appetite or weight (e.g., diabetes mellitus, thyroid disease) * Recent pregnancy or breastfeeding (prior 6 months) * Relevant food allergies (e.g., wheat, chocolate) * Specific phobia, blood-injection-injury type * Medical condition that precludes safe participation in exercise (e.g., stress fracture) * Medications that acutely affect appetite (e.g., GLP-1 agonists; psychiatric medications allowed)

Locations (1)

Ohio University

Athens, Ohio, United States

RECRUITING

Outcomes

Primary Outcomes

Relative Energy Intake

Relative energy intake for 24 hours will be calculated as absolute energy intake from the breakfast (if consumed), lunch, food reward value task, and take home cooler minus energy expenditure during exercise (or comparable time period during rest).

Time frame: Food intake from 8 am to 8 am; Energy expenditure from approximately 9 am to 9:05 am and 9:25 to 9:30 am, coinciding with study condition (rest or exercise)

Secondary Outcomes

Lactate

Lactate values

Time frame: 30 minutes, pre-post exercise (or rest)

Acylated ghrelin

Time frame: Immediately prior to lunch

Self-reported binge eating

Participants will rate the extent the following questions, considering the time frame "since yesterday morning at 8 am" on a 1 to 5 scale from "not at all" to "extremely": "While you were eating, to what extent did you feel a sense of loss of control?," "While you were eating, to what extent did you feel that you could not resist eating," "While you were eating, to what extent did you feel that you could not stop eating once you had started," and "While you were eating, to what extent did you feel driven or compelled to eat?" An answer of 4 or higher on any item will be categorized as binge eating present. Any reported binge eating on either day will be coded as binge eating being present

Time frame: 24 and 48 hours after exercise/rest study visit

Food reward value

Number of trials according to task developed by Bodell and Keel 2015

Time frame: Approximately 3:30 pm day of study visit

Central Contacts

K. Jean Forney, Ph.D.

CONTACT

740-593-1085 forney@ohio.edu

Data from ClinicalTrials.gov

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