The Role of Postoperative Antibiotics in Laparoscopic Cholecystectomy

Phase 4RecruitingNCT06607887

Minia University Hospital300 enrolled

Overview

Comparison between postoperative parenteral prophylactic antibiotics, and oral antibiotics regarding the incidence of post laparoscopic cholecystectomy infection.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

300

Conditions

Infection Wound Antibiotic Resistant Infection

Interventions

IV antibioticDRUG

Parenteral prophylactic antibiotics (cefazolin), 1st dose at the time of induction of anesthesia, 2nd dose after 12hs from the surgery.

Oral antibioticDRUG

Parenteral prophylactic antibiotic (cefazolin), dose at the time of induction of anesthesia and then oral antibiotic for five days postoperative.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients (aged above 18 years) undergoing laparoscopic cholecystectomy. Exclusion Criteria: * patients with comorbidities (Diabetes, malignancies, Immunosuppressed). Lost of follow-up. Patients received antibiotics within 72 hr before admission. Complicated cases involved, gangrenous and perforated cholecystitis and abscess.

Locations (1)

Minia University Hospital

Minya, Egypt

RECRUITING

Outcomes

Primary Outcomes

Surgical site infection

DSSI = deep surgical site infection; SSSI = superficial surgical site infection.

Time frame: 4 weeks

Secondary Outcomes

Fever

Time frame: 4 weeks

Length of the hospital stay

Time frame: 4 weeks

Hematoma and Seroma formation

Time frame: 4 weeks

Central Contacts

Asmaa A Elsayed

CONTACT

01095727201 asmaa.abdelfattah@pharm.sohag.edu.eg

Data from ClinicalTrials.gov

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