Efficacy and Safety of TTM in Adults With ECPR.

Inclusion Criteria: 1. Patients aged ≥18 and ≤60 years; 2. Patients with in-hospital and out-of-hospital cardiac arrest of any initial rhythm; 3. Patients who have received cardiopulmonary resuscitation for \>10 minutes without achieving return of spontaneous circulation; 4. Patients with a reversible cause of cardiac arrest (acute myocardial infarction, pulmonary embolism, all initial defibrillatable rhythm, cardiomyopathy); Exclusion Criteria: 1. cardiac arrest due to trauma; 2. pregnant and lactating women; 3. unwitnessed cardiac arrest; 4. out-of-hospital cardiac arrest not receiving CPR within 5 minutes; 5. \> 60 minutes from the onset of cardiac arrest to the initiation of extracorporeal cardiopulmonary resuscitation; 6. achievement of return of spontaneous circulation before the start of external cardiopulmonary resuscitation; 7. intracranial hemorrhage or suspected intracranial hemorrhage; 8. pre-existing neurologic impairment (CPC ≥ 3) prior to the onset of cardiac arrest; 9. those with end-stage heart failure; 10. those with new-onset cerebral hemorrhage or cerebral infarction; 11. other vascular conditions such as severe plaque in bilateral femoral arteries that cause difficulty in tube placement; 12. patients with combined malignant tumors; 13. other serious diseases with a life expectancy of \<1 year; 14. refusal to perform extracorporeal cardiopulmonary resuscitation and/or target temperature administrators. 15. Temperature \<30°C.